Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Controls
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Drug Derivative Related Products (4062)
Related Products (4062)
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3',4'-Dimethyl-α-pyrrolidinovalerophenone hydrochloride
0 ImagesCat. No.: HY-168422CAS No.: 2748485-15-43',4'-Dimethyl-α-pyrrolidinovalerophenone hydrochloride is a drug derivative.
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Asparaginate calcium
0 ImagesCat. No.: HY-W802239CAS No.: 39162-75-9Asparaginate calcium is a calcium2+ salt of asparaginate and anion/zwitterion form of aspartic acid. Asparaginate calcium is a calcium supplement and an antiarrhythmic active substance. Asparaginate calcium can be used for the research of arrhythmia.
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Alaschanioside A
0 ImagesCat. No.: HY-N16968CAS No.: 157446-63-4Alaschanioside A is a natural lignan.
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Plicatinaphthol
0 ImagesCat. No.: HY-N17193CAS No.: 22127-07-7Plicatinaphthol is a natural lignan.
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Leptabiside C
0 ImagesCat. No.: HY-N16999CAS No.: 1900703-81-2Leptabiside C is a natural phenolic compound.
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Eicosapentaenoyl 1-propanol-2-amide
0 ImagesCat. No.: HY-139272CAS No.: 1638355-66-4Eicosapentaenoyl 1-propanol-2-amide is an amide derivative of Eicosapentaenoic Acid (HY-B0660). Eicosapentaenoyl 1-propanol-2-amide inhibits the 98.4% proliferation of cancer cell A549 at 3 μM. Eicosapentaenoyl 1-propanol-2-amide can be used in cancer research.
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ISR/ROS-activator-1
0 ImagesCat. No.: HY-184243CAS No.: 3099924-90-7ISR/ROS-activator-1 is a naphthoquinone compound derived from Shikonin (HY-N0822), and also dual activator of the ISR/ROS pathway. ISR/ROS-activator-1 induces Apoptosis and Ferroptosis. ISR/ROS-activator-1 selectively inhibits gastric cancer. ISR/ROS-activator-1 is applicable to gastric cancer-related research.
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Spiradine G
0 ImagesCat. No.: HY-N16824CAS No.: 21040-66-4Spiradine G is a natural alkaloid.
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Moracin K
0 ImagesCat. No.: HY-N17506CAS No.: 73338-90-6Moracin K is a prenylated arylbenzofuran derivative. Moracin K is present in the trunk bark of Morus mesozygia.
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2α,17α-Diethynyl-A-nor-5α-androstane-2β,17β-diol diacetate
0 ImagesCat. No.: HY-123712CAS No.: 70226-89-02α,17α-Diethynyl-A-nor-5α-androstane-2β,17β-diol diacetate is an active compound.
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Dihydroauroglaucin
0 ImagesCat. No.: HY-N17160CAS No.: 77102-91-1Dihydroauroglaucin is a natural phenolic compound.
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Rapamycin analog-2
0 ImagesCat. No.: HY-153511CAS No.: 2357217-22-0Rapamycin analog-2 (compound A) is a Rapamycin analog.
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Microtubule destabilizing agent-3, negative control
0 ImagesCat. No.: HY-179696CAS No.: 2734582-91-1destabilizing agent-3 (HY-179695). Microtubule destabilizing agent-3 is a microtubule destabilizing agent. Microtubule destabilizing agent-3 exerts its antimyeloma phenotypes by destabilizing microtubules and promoting mitotic arrest, leading to cell death. Microtubule destabilizing agent-3 induces G2/M phase arrest and caspase-dependent apoptosis.
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Daphnezomine B
0 ImagesCat. No.: HY-N16943CAS No.: 247078-43-9Daphnezomine B is a natural alkaloid.
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Aristeromycin 5′-diphosphate
0 ImagesCat. No.: HY-182249CAS No.: 42578-93-8Synonyms: ArDPAristeromycin (ArDP) 5′-diphosphate is a carbocyclic nucleotide analog of adenosine diphosphate (ADP). Aristeromycin 5′-diphosphate acts as a key intermediate in the synthesis of bioactive compounds.
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Δ16-Adynerin gentiobioside
0 ImagesCat. No.: HY-N3703CAS No.: 143212-60-6Δ16-Adynerin gentiobioside is a natural steroid.
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Lycoramine hydrobromide
0 ImagesCat. No.: HY-N6619CAS No.: 89505-76-0Lycoramine hydrobromide is a blood-brain barrier-penetrating Acetylcholinesterase inhibitor and Galanthamine (HY-76299) derivative. Lycoramine hydrobromide induces Amyloid-beta plaque clearance. Lycoramine hydrobromide induces reversal of cognitive decline and memory improvement. Lycoramine hydrobromide can be used for research on Alzheimer's disease and myasthenia gravis.
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2-(Phenylethynyl)-ATP
0 ImagesCat. No.: HY-107752CAS No.: 851265-78-6
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G-quadruplex ligand 4
0 ImagesCat. No.: HY-179480G-quadruplex ligand 4 is a chromenone derivative and is a human telomerase reverse transcriptase (hTERT) G4 ligand. G-quadruplex ligand 4 downregulates hTERT expression and exhibits notable cytotoxicity towards triple-negative breast cancer (TNBC) cell lines. G-quadruplex ligand 4 can cause S/G2 cell cycle arrest and induce apoptosis. G-quadruplex ligand 4 downregulates the expression of hTERT, KRAS, and BCL-2. G-quadruplex ligand 4 can be used for the research of TNBC.
