Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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PB-22 8-Hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172053CAS No.: 1798021-82-5PB-22 8-Hydroxyisoquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(S)-VAV1 degrader-1
0 ImagesCat. No.: HY-W1118851CAS No.: 3050683-64-9(S)-VAV1 degrader-1 is a VAV1 molecular glue degrader with DC50 = 3.07 nM. (S)-VAV1 degrader-1 is used for research on VAV1-related diseases, such as inflammation and immune-related diseases.
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Oxiran-2-ylmethanol (Standard)
0 ImagesOxiran-2-ylmethanol (Standard) is the analytical standard of Oxiran-2-ylmethanol (Glycidol) (HY-Y1010). This product is intended for research and analytical applications. Oxiran-2-ylmethanol is an ester product. Oxiran-2-ylmethanol induces base pair point mutations in bacterial strains and structural chromosome aberrations in cultured cells. Oxiran-2-ylmethanol forms N-(2,3-dihydroxypropyl)valine hemoglobin adducts. Oxiran-2-ylmethanol acts as an animal carcinogen but does not significantly induce micronucleated immature erythrocytes in animal bone marrow. Oxiran-2-ylmethanol enables anionic polymerization to produce linear poly(glycidol). Oxiran-2-ylmethanol can be used for cancer-related research.
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(S)-Trolox (Standard)
0 ImagesCat. No.: HY-101445BRCAS No.: 53174-06-4(S)-Trolox (Standard) is the analytical standard of (S)-Trolox (HY-101445B). This product is intended for research and analytical applications. (S)-Trolox is an analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects.
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(22R)-Budesonide
0 ImagesCat. No.: HY-125922CAS No.: 51372-29-3Synonyms: (22R)-BUD(22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity.
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(R)-RXFP2 agonist 2
0 ImagesCat. No.: HY-150186ACAS No.: 3123585-08-7(R)-RXFP2 agonist 2 is the R-type isomer of RXFP2 agonist 2 (HY-150186). RXFP2 agonist 2 is a selective, orally active and allosteric RXFP2 agonist with an EC50 value of 0.38 μM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis.
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(S)-SKF 38393
0 ImagesCat. No.: HY-12520CCAS No.: 81702-43-4(S)-SKF 38393 is the S-enantiomer of SKF 38393 (HY-12520). (S)-SKF 38393 shows no activity against the D1 dopamine receptor, with an IC50 of 10700 nM. (S)-SKF 38393 can be used in the research of neurological diseases.
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7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione
![7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione](https://file.medchemexpress.com/product_pic/hy-169261.gif "Click to View 7-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione Product Detail")
0 ImagesCat. No.: HY-169261CAS No.: 859304-28-27-Methoxy-9-methylfuro[2,3-b]-quinoline-4,5,8(9H)-trione is a synthetic intermediate that can been used in the synthesis of the alkaloid Acronycidine.
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(-)-Epipinoresinol
0 ImagesCat. No.: HY-N7534ACAS No.: 10061-38-8(-)-Epipinoresinol is an isomer of the lignan (+)-Epipinoresinol. CYP81Q3 specifically catalyzes the formation of the methylenedioxy bridge (MDB) in (+)-Epipinoresinol to produce (+)-Pluviatilol.
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PB-22 5-Hydroxyquinoline isomer
0 ImagesCat. No.: HY-172040CAS No.: 1885091-23-5PB-22 5-hydroxyquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(2S,3R)-Fadraciclib
0 ImagesCat. No.: HY-101212A(2S,3R)-Fadraciclib is the 2S,3R isomer of Fadraciclib (HY-101212). Fadraciclib is an orally potent ATP-competitive CDK2/CDK9 kinase inhibitor with IC50 values of 5 and 26 nM, respectively.
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Isomalathion
0 ImagesCat. No.: HY-W707749CAS No.: 3344-12-5Isomalathion is an isomer and impurity of Malathion (HY-B0943). Isomalathion inhibits Carboxyesterase and AChE, with an IC50 value of 3.2 μM against bovine acetylcholinesterase. Isomalathion moderately reduces CYP1A2 transcript levels, increases CYP2B6 transcript levels, and induces dose-dependent DNA damage. Malathion is an organophosphorus insecticide.
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(R)-Ozanimod hydrochloride
0 ImagesCat. No.: HY-W751034ACAS No.: 1306760-85-9Synonyms: (R)-RPC-1063 hydrochloride(R)-Ozanimod (hydrochloride) is the R-isomer of Ozanimod hydrochloride (HY-12288A).
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(Rac)-Germacrene D
0 ImagesCat. No.: HY-129155CAS No.: 37839-63-7(Rac)-Germacrene D is a natural product that can be isolated from the genus Bursera.
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2-Hydroxymethyl-5-hydroxypyridine (Standard)
0 ImagesCat. No.: HY-W007140RCAS No.: 40222-77-32-Hydroxymethyl-5-hydroxypyridine (Standard) is the analytical standard of 2-Hydroxymethyl-5-hydroxypyridine (HY-W007140). This product is intended for research and analytical applications. 2-Hydroxymethyl-5-hydroxypyridine is isolated from the the matured, ripened and dried seeds of S. lychnophora.
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(1R)-1,2-Dilauroyl-sn-glycerol
0 ImagesCat. No.: HY-128465ACAS No.: 61475-84-1(1R)-1,2-Dilauroyl-sn-glycerol is the R isomer of 1,2-Dilauroyl-sn-glycerol (HY-128465). 1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol and may play a role in second messenger signal transduction.
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PB-22 6-Hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172051CAS No.: 1797131-58-8PB-22 6-Hydroxyisoquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(Z)-JIB-04 (Standard)
0 ImagesCat. No.: HY-107842RCAS No.: 199596-24-2Synonyms: NSC693627 (Standard)(Z)-JIB-04 (Standard) is the analytical standard of (Z)-JIB-04 (HY-107842). This product is intended for research and analytical applications. (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis.
