Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Cefetamet sodium
0 ImagesCat. No.: HY-A0111ACAS No.: 65243-25-6Synonyms: Ro15-8074/001; Deacetoxycefotaxime sodiumCefetamet (Ro 15-8074) sodium is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet sodium binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet sodium has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet sodium kills and lyses Treponema pallidum. Cefetamet sodium can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
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3-Hydroxy darifenacin
0 ImagesCat. No.: HY-149504CAS No.: 206048-82-03-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells.
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Nirvanol (Standard)
0 ImagesCat. No.: HY-W012481RCAS No.: 631-07-2Synonyms: Ethylphenylhydantoin (Standard); Phenylethyihydantoin (Standard); Desmethylmephenytoin (Standard)Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders.
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RL-603
0 ImagesRL-603 is the metabolite of Anagrelide (HY-B0523). RL-603 exhibits platelet-lowering activity in mouse model.
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Rivaroxaban diol
0 ImagesCat. No.: HY-137070CAS No.: 1160170-00-2Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903). Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM).
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p,p'-DDE-13C12
0 ImagesCat. No.: HY-W753141CAS No.: 201612-50-2Synonyms: 4,4'-DDE-13C12; p,p'-Dichlorodiphenyldichloroethylene-13C12p,p'-DDE-13C12 is 13C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.
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(S)-Menthiafolic acid
0 ImagesCat. No.: HY-N15533CAS No.: 75979-26-9(S)-Menthiafolic acid is a component found in wines and grape juices. (S)-Menthiafolic acid can be generated from the grape-derived (S)-menthiafolic acid glucose ester during alcoholic and malolactic fermentation, thereby influencing the aroma components of wine.
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CNJ-294
0 ImagesCat. No.: HY-169878CAS No.: 1029713-99-2CNJ-294 is an intermediate in the synthesis of Capmatinib (HY-13404) and a metabolite of Capmatinib (HY-13404).
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Febuxostat impurity 8 (Standard)
0 ImagesCat. No.: HY-131270RCAS No.: 144060-62-8Febuxostat impurity 8 (Standard) is the analytical standard of Febuxostat impurity 8. This product is intended for research and analytical applications. Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
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Spirotetramat-keto-hydroxy
0 ImagesCat. No.: HY-W714239CAS No.: 1172134-11-0Spirotetramat-keto-hydroxy is a metabolite of Spirotetramat (HY-120253). Spirotetramat is an insecticide.
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N-Desethyl Sunitinib (Standard)
0 ImagesCat. No.: HY-10873RCAS No.: 356068-97-8Synonyms: SU-12662 (Standard)N-Desethyl Sunitinib (Standard) is the analytical standard of N-Desethyl Sunitinib. This product is intended for research and analytical applications. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].
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N-Depropylpropafenone
0 ImagesCat. No.: HY-W803860CAS No.: 86383-21-3N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects.
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6-O-Demethyl griseofulvin
0 ImagesCat. No.: HY-W741491CAS No.: 20168-88-1Synonyms: 6-Demethylgriseofulvin; 6-Desmethylgriseofulvin6-O-Demethyl griseofulvin is a metabolite of Griseofulvin (HY-17583).
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Captopril EP Impurity C
0 ImagesSynonyms: 3-Mercaptoisobutyric acidCaptopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
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Ramelteon metabolite M-II (Standard)
0 ImagesCat. No.: HY-103005RCAS No.: 896736-21-3Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
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Permethric acid
0 ImagesCat. No.: HY-W144077CAS No.: 55701-05-8Permethric acid is a metabolite of insecticide permethrin.
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Mitoxantrone carboxylic acid
0 ImagesCat. No.: HY-187767CAS No.: 97729-56-1Mitoxantrone carboxylic acid is the monocarboxylic acid metabolite of the antitumor agent Mitoxantrone (HY-13502). Mitoxantrone carboxylic acid is formed by oxidation of the terminal hydroxyl group on the side chain, and serves as one of the major metabolites in both humans and rabbits, which is mainly excreted via bile. Mitoxantrone carboxylic acid can be used as an HPLC reference marker for pharmacokinetic and metabolic studies of Mitoxantrone.
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(Rac)-Mono(3,5,5-trimethylhexyl) phthalate
0 ImagesCat. No.: HY-133672CAS No.: 297182-83-3(Rac)-Mono(3,5,5-trimethylhexyl) phthalate is a important metabolite of commonly used phthalate plasticizers. (Rac)-Mono(3,5,5-trimethylhexyl) phthalate has immuno-suppressive effect.
