Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Captopril EP Impurity C (Standard)
0 ImagesCat. No.: HY-137769RCAS No.: 26473-47-2Synonyms: 3-Mercaptoisobutyric acid (Standard)Captopril EP Impurity C (Standard) is the analytical standard of Captopril EP Impurity C. This product is intended for research and analytical applications. Captopril EP Impurity C is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
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Norverapamil
0 ImagesCat. No.: HY-135328CAS No.: 67018-85-3Synonyms: (±)-Norverapamil; D591Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
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Captopril EP Impurity B (Standard)
0 ImagesCat. No.: HY-137768RCAS No.: 80629-35-2Captopril EP Impurity B (Standard) is the analytical standard of Captopril EP Impurity B. This product is intended for research and analytical applications. Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
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Fenirofibrate
0 ImagesCat. No.: HY-118527CAS No.: 54419-31-7Synonyms: LF 2151Fenirofibrate (LF 2151), a metabolite of Fenofibrate (HY-17356), is an orally active fibrate, used in the study of hypertriglyceridemia.
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Gemcitabine 5'-diphosphate
0 ImagesCat. No.: HY-W791041CAS No.: 116371-66-5Synonyms: dFdCDPGemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects.
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Chlorthalidone impurity (Standard)
0 ImagesChlorthalidone impurity (Standard) is the analytical standard of Chlorthalidone impurity. This product is intended for research and analytical applications. Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
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Ro 44-3888
0 ImagesCat. No.: HY-187608CAS No.: 144412-18-0Ro 44-3888 is an orally active and selective GP IIb-IIIa (fibrinogen receptor, integrin αIIbβ3) inhibitor with an IC50 of 1.9 nM against the human target. Ro 44-3888 blocks the binding of fibrinogen to GP IIb-IIIa and inhibits human ADP-induced platelet aggregation. Ro 44‑3888 is formed via the metabolism of the double prodrug Ro 48‑3657 (HY-10309). Ro 44-3888 is used in studies related to arterial thrombosis.
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MD 770222
0 ImagesCat. No.: HY-124464CAS No.: 70133-35-6MD 770222, a major plasma O-demethyl metabolite of Cimoxatone (HY-15386), is an orally active, selective and reversible MAO A inhibitor. MD 770222 shows less potent than Cimoxatone.
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4'-Hydroxytamoxifen TFA (Standard)
0 ImagesCat. No.: HY-124414AR4'-Hydroxytamoxifen (TFA) (Standard) is the analytical standard of 4'-Hydroxytamoxifen (TFA). This product is intended for research and analytical applications. 4'-Hydroxytamoxifen TFA is a salt form of a metabolite of Tamoxifen. 4'-Hydroxytamoxifen TFA has a higher affinity for ER than Tamoxifen. 4'-Hydroxytamoxifen TFA induces non-apoptotic cytotoxicity in human endometrial adenocarcinoma cells[1].
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Desisopropyl-fesoterodine
0 ImagesCat. No.: HY-180471CAS No.: 1361197-33-2Desisopropyl-fesoterodine (compound 1), an oxidative Ndealkylation of the tertiary amine function of Fesoterodine (HY-70053), is a degradation product (compound PP-6) of Fesoterodine.
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Triflumizole-amino
0 ImagesCat. No.: HY-W726614ACAS No.: 131549-75-2Triflumizole-amino is the main metabolite of Triflumizole (HY-W020777). Triflumizole is an imidazole fungicide.
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(rac)-5-Hydroxykynurenine
0 Images(rac)-5-Hydroxykynurenine is a urinary metabolite. (rac)-5-Hydroxykynurenine is generated via indole ring oxidative cleavage of 5-hydroxytryptophan (HY-N0122) catalyzed by indoleamine 2,3-dioxygenase.
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RPR121056 (Standard)
0 ImagesSynonyms: APC (Standard)RPR121056 (Standard) is the analytical standard of RPR121056. This product is intended for research and analytical applications. RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].
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Dihydroartemisinin-d
0 ImagesCat. No.: HY-N0176S6CAS No.: 252043-36-0Synonyms: Dihydroqinghaosu-d; β-Dihydroartemisinin-d; Artenimol-dDihydroartemisinin-d (Dihydroqinghaosu-d) is the d-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is an orally active metabolite of rtemisinin (HY-B0094) and antimalarial agent. Dihydroartemisinin induces Autophagy by inhibiting NF-κB activation. Dihydroartemisinin promotes ROS accumulation. Dihydroartemisinin exhibits anticancer activity in esophageal cancer cells. Dihydroartemisinin shows schistosomicidal activity against juvenile and adult worms of Schistosoma japonicum, reduces worm burden, and displays antiparasitic activity. Dihydroartemisinin can be used in research related to multiple myeloma, promyelocytic leukemia, esophageal cancer, and Schistosoma japonicum infection.
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3-(1-Nitrosopyrrolidin-2-yl)pyridine-13C6
0 ImagesCat. No.: HY-W768044CAS No.: 2726380-44-33-(1-Nitrosopyrrolidin-2-yl)pyridine-13C6 is the 13C-labeled 3-(1-Nitrosopyrrolidin-2-yl)pyridine (HY-W189682). 3-(1-Nitrosopyrrolidin-2-yl)pyridine is a major tobacco-specific nitrosamine.
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O-Desmethyl Mebeverine alcohol hydrochloride (Standard)
0 ImagesCat. No.: HY-G0008ARCAS No.: 856620-39-8Synonyms: Mebeverine metabolite O-desmethyl Mebeverine alcohol hydrochloride (Standard)Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments.
