Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Lofendazam
0 ImagesCat. No.: HY-184368CAS No.: 29176-29-2Lofendazam is a major metabolite of Arfendazam. Lofendazam acts as a positive allosteric modulator/partial agonist of GABAa receptor, with IC50 values of 10.1 nM and 9.1 nM in bovine cerebral cortex and bovine cerebellum, respectively; its in vivo ED50 via oral administration is 233 µmol/kg.
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Zolpyridine
0 ImagesCat. No.: HY-W518478CAS No.: 349122-64-1Zolpyridine is a degradation product of Zolpidem tartrate.
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5-Oxo Pitavastatin
0 ImagesCat. No.: HY-137026CAS No.: 222306-15-25-Oxo Pitavastatin (M-3) is the metabolite of Pitavastatin (HY-B0144A). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.
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3'-Hydroxy simvastatin
0 Images3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research.
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13(S)-HODE-biotin
0 ImagesCat. No.: HY-157253CAS No.: 1217458-58-613(S)-HODE is the lipoxygenase metabolite of Linoleic acid (HY-N0729). 13(S)-HODE modulates the platelet-activating factor, leukotriene B4, and formyl-Met-Leu-Phe-induced calcium influx in human polymorphonuclear leukocytes.
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8-Hydroxychlorpromazine
0 Images8-Hydroxychlorpromazine is a metabolite of Chlorpromazine (HY-12708) that can enhance the hyperglycemic response following a glucose load, suggesting its potential synergistic role in Chlorpromazine-induced glucose metabolism disorders. 8-Hydroxychlorpromazine may be useful for research in metabolic diseases.
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1-Aminohydantoin hydrochloride (Standard)
0 Images1-Aminohydantoin hydrochloride (Standard) is the analytical standard of 1-Aminohydantoin hydrochloride (HY-Y0469). This product is intended for research and analytical applications. 1-Aminohydantoin hydrochloride is a major metabolite of Nitrofurantoin (HY-A0090) in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of 1-Aminohydantoin hydrochloride before detection.
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Homoeriodictyol (Standard)
0 ImagesHomoeriodictyol (Standard) is the analytical standard of Homoeriodictyol (HY-N8210). This product is intended for research and analytical applications. Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo.
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N-Acetyl Adamantamine
0 ImagesN-Acetyl Adamantamine (1-Acetamidoadamantane) is a major metabolite of Amantadine (HY-B0402)[1].
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Captopril EP Impurity B
0 ImagesCat. No.: HY-137768CAS No.: 80629-35-2Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
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Etodolac acyl glucuronide
0 ImagesCat. No.: HY-W700465CAS No.: 79541-43-8
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Zopiclone impurity-1
0 ImagesSynonyms: RP 29307Zopiclone impurity-1 (RP 29307) is an impurity and degradation product in the production process of zopiclone.
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Captopril EP Impurity J
0 ImagesCat. No.: HY-W013886CAS No.: 64838-55-7Synonyms: S-AcetylcaptoprilCaptopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
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3-HC-Gluc
0 ImagesCat. No.: HY-160251CAS No.: 132929-88-5Synonyms: (3'R,5k'S)-trans-3'-Hydroxycotinine glucuronide3-HC-Gluc ((3’R,5k’s)-trans-3’ -Hydroxycotinine glucuronide) The trans-structure of 3-HC, the main metabolite of nicotine.
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(±)13(14)-DiHDPA
0 ImagesCat. No.: HY-158623CAS No.: 1345275-24-2Synonyms: (±)13,14-DiHDPE(±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways.
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α-Hydroxy Montelukast
0 ImagesCat. No.: HY-131396CAS No.: 2045402-27-3
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Deacetyltrimepranol
0 ImagesCat. No.: HY-133827CAS No.: 57193-14-3Synonyms: DeacetylmetipranololDeacetyltrimepranol (Deacetylmetipranolol) is the active metabolite of metipranolol (HY-121567), a β-adrenergic receptor blocker. Deacetyltrimepranol can be used in the research of hypertension.
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Netupitant N-oxide-d6
0 ImagesCat. No.: HY-G0011SCAS No.: 2070015-12-0Netupitant N-oxide-d6 is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.
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Tyrene
0 ImagesCat. No.: HY-W097929CAS No.: 87-40-1Synonyms: 2,4,6-TrichloroanisoleTyrene (2,4,6-Trichloroanisole) is an off-flavor compound, cyclic nucleotide-gated (CNG) channel inhibitor, and olfactory transduction attenuator. Tyrene is formed by microbial O-methylation of 2,4,6-trichlorophenol. Tyrene inhibits channel activity in olfactory receptor cells by partitioning into the plasma membrane lipid bilayer, and also suppresses odorant- and cAMP-induced currents in individual olfactory receptor cells. Tyrene causes cork taint in wine. Tyrene also produces off-flavors in potato chips, dried fruits, coffee, and drinking water.
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Dihydroechinofuran
0 ImagesCat. No.: HY-171238CAS No.: 142130-52-7Dihydroechinofuran is an abenzoquinone metabolite.
