Epigenetic Reader Domain
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Epigenetic Reader Domain Inhibitors
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Epigenetic Reader Domain Substrate
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Epigenetic Reader Domain Ligands
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Epigenetic Reader Domain Related Products (447)
Related Products (447)
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Birabresib (Standard)
0 ImagesSynonyms: OTX-015 (Standard); MK-8628 (Standard)Birabresib (Standard) is the analytical standard of Birabresib. This product is intended for research and analytical applications. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.
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F2276-0008
0 ImagesCat. No.: HY-153147CAS No.: 922000-45-1F2276-0008 is a potential PCAF bromodomain (PDB 5FDZ) inhibitor. F2276-0008 is predicted to have good cell permeability and oral absorption. F2276-0008 exhibits a stable C-alpha backbone RMSD and maintains compactness. F2276-0008 can be used for cancer-related research.
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ZEN-3219 (Standard)
0 ImagesCat. No.: HY-111977RCAS No.: 1952264-34-4ZEN-3219 (Standard) is the analytical standard of ZEN-3219 (HY-111977). This product is intended for research and analytical applications. ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4.
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Vadenersen
0 ImagesCat. No.: HY-185935CAS No.: 3027256-85-2Vadenersen is an inhibitor of MECP2 protein expression. Vadenersen has potential for research into Rett syndrome.
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(±)-JQ1
0 ImagesCat. No.: HY-137075CAS No.: 1268524-69-1
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BRD4 Inhibitor-33
0 ImagesCat. No.: HY-160660CAS No.: 1445993-17-8BRD4 Inhibitor-33 (example 13) is a BRD4 inhibitor that can be used in acute kidney disease and chronic kidney disease research.
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I-BET762 carboxylic acid (Standard)
0 ImagesCat. No.: HY-107443RCAS No.: 1300019-38-8Synonyms: Molibresib carboxylic acid (Standard); GSK525762A carboxylic acid (Standard); PROTAC BRD4-binding moiety 2 (Standard)I-BET762 carboxylic acid (Standard) is the analytical standard of I-BET762 carboxylic acid (HY-107443). This product is intended for research and analytical applications. I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1.
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NI-42 (Standard)
0 ImagesCat. No.: HY-101121RCAS No.: 1884640-99-6NI-42 (Standard) is the analytical standard of NI-42 (HY-101121). This product is intended for research and analytical applications. NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins.
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Mivebresib (Standard)
0 ImagesSynonyms: ABBV-075 (Standard)
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CPI-637 (Standard)
0 ImagesCat. No.: HY-100482RCAS No.: 1884712-47-3CPI-637 (Standard) is the analytical standard of CPI-637 (HY-100482). This product is intended for research and analytical applications. CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.
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IACS-9571 hydrochloride (Standard)
0 ImagesSynonyms: ASIS-P040 hydrochloride (Standard)IACS-9571 hydrochloride (Standard) is the analytical standard of IACS-9571 hydrochloride (HY-102000B). This product is intended for research and analytical applications. IACS-9571 (ASIS-P040) hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.
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PROTAC BRD4-binding moiety 1 (Standard)
0 ImagesCat. No.: HY-107442RCAS No.: 2101200-10-4PROTAC BRD4-binding moiety 1 (Standard) is the analytical standard of PROTAC BRD4-binding moiety 1 (HY-107442). This product is intended for research and analytical applications. PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136). PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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PLX51107 (Standard)
0 ImagesCat. No.: HY-111422RCAS No.: 1627929-55-8PLX51107 (Standard) is the analytical standard of PLX51107 (HY-111422). This product is intended for research and analytical applications. PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range).
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Menin-MLL-IN-35
0 ImagesCat. No.: HY-186043CAS No.: 2654080-48-3Menin-MLL-IN-35 (compound 286) is an inhibitor of menin/MLL protein/protein interaction with an IC50 value of 0.096 μM in MEIS1 mRNA expression. Menin-MLL-IN-35 can be used in the research of cancer, myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), and diabetes.
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BI 2536 (Standard)
0 ImagesCat. No.: HY-50698RCAS No.: 755038-02-9
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GSK4028 (Standard)
0 ImagesCat. No.: HY-101027ARCAS No.: 2079886-19-2GSK4028 (Standard) is the analytical standard of GSK4028 (HY-101027A). This product is intended for research and analytical applications. GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
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FL-411 (Standard)
0 ImagesCat. No.: HY-111102RCAS No.: 2118944-88-8Synonyms: BRD4-IN-1 (Standard)
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SB-699551 (Standard)
0 ImagesCat. No.: HY-103100RCAS No.: 864741-95-7SB-699551 (Standard) is the analytical standard of SB-699551 (HY-103100). This product is intended for research and analytical applications. SB-699551 is a potent and selective 5-HT5A antagonist with a Ki value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1, and decreases the phosphorylation levels of AKT, PRAS40, P70S6K, FOXO1, and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer.
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I-CBP112 hydrochloride
0 ImagesCat. No.: HY-19541ACAS No.: 2147701-33-3I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively). I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
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SGC-CBP30 (Standard)
0 ImagesCat. No.: HY-15826RCAS No.: 1613695-14-9SGC-CBP30 (Standard) is the analytical standard of SGC-CBP30 (HY-15826). This product is intended for research and analytical applications. SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects.
