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Cat. No.: HY-137075

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(±)-JQ1

Name: (±)-JQ1
Brand: MedChemExpress
SKU: HY-137075
Price: 168.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(±)-JQ1 is the racemate of (+)-JQ-1 (HY-13030).

For research use only. We do not sell to patients.

CAS No.: 1268524-69-1
Formula: C₂₃H₂₅ClN₄O₂S
Molecular Weight:456.99

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (272 KB)

(±)-JQ1 Chemical Structure

CAS No.: 1268524-69-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(±)-JQ1 is the racemate of (+)-JQ-1 (HY-13030)^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	EC₅₀	2037 nM Compound: 2; JQ-1	Antiproliferative activity against human CCRF-CEM cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human CCRF-CEM cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
DOHH-2	EC₅₀	279 nM Compound: 2; JQ-1	Antiproliferative activity against human DOHH2 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human DOHH2 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
HEK293	CC₅₀	>20 μM Compound: JQ1	Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay	[PMID: 30973727]
HEL 92.1.7	EC₅₀	180 nM Compound: 2; JQ-1	Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
HepG2	CC₅₀	9.2 μM Compound: JQ1	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay	[PMID: 30973727]
HL-60	EC₅₀	51 nM Compound: 2; JQ-1	Antiproliferative activity against human HL60 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human HL60 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
K562	EC₅₀	>10000 nM Compound: 2; JQ-1	Antiproliferative activity against human K562 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human K562 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
MCF7	IC₅₀	28.75 μM Compound: 1; JQ1	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 29172540]
MDA-MB-231	IC₅₀	33.04 μM Compound: 1; JQ1	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 29172540]
MV4-11	EC₅₀	39 nM Compound: 2; JQ-1	Antiproliferative activity against human MV4-11 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human MV4-11 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
MV4-11	IC₅₀	72.2 nM Compound: JQ-1	Antiproliferative activity against human MV4-11 cells Antiproliferative activity against human MV4-11 cells	[PMID: 35714446]
Raji	EC₅₀	330 nM Compound: 2; JQ-1	Antiproliferative activity against human Raji cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human Raji cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
RPMI-8226	EC₅₀	258 nM Compound: 2; JQ-1	Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
SUD4	EC₅₀	660 nM Compound: 2; JQ-1	Antiproliferative activity against human SU-DHL4 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human SU-DHL4 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]

Chemical Information

CAS No. 1268524-69-1
Appearance Solid
Molecular Weight 456.99
Formula C₂₃H₂₅ClN₄O₂S
Color White to off-white
SMILES

O=C(OC(C)(C)C)CC1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shameem Sultana Syeda, et al. Scalable syntheses of the BET bromodomain inhibitor JQ1. Tetrahedron Lett. 2015 Jun 3;56(23):3354-3457. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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(±)-JQ1

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