1. PROTAC
    Epigenetics
  2. PROTAC
    Epigenetic Reader Domain
  3. PROTAC BRD4 Degrader-2

PROTAC BRD4 Degrader-2 

Cat. No.: HY-133136
Handling Instructions

PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-2 Chemical Structure

PROTAC BRD4 Degrader-2 Chemical Structure

CAS No. : 2185795-53-1

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Description

PROTAC BRD4 Degrader-2 is an efficacious PROTAC BRD4 degrader with an IC50 of 14.2 nM against BRD4 BD1[1].

IC50 & Target

BRD4 BD1

14.2 nM (IC50)

Cereblon

 

In Vitro

PROTAC BRD4 Degrader-2 (Compound 17) inhibits the growth of THP-1 cell line with an IC50 of 1.83±0.016 μM[1].

Cell Proliferation Assay[1]

Cell Line: Human monocyte lymphoma cell line THP-1
Concentration: 72 hours
Incubation Time: 0.81-3.26 μM
Result: Showd high anti-proliferative potency.
Molecular Weight

757.79

Formula

C₄₀H₃₉N₉O₇

CAS No.

2185795-53-1

SMILES

O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)COCCN4N=NC(CN5C(N(C)C6=C(C=C(C7=C(C)ON=C7C)C=C6)C5C8=CC=CC=C8)=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PROTAC BRD4 Degrader-2PROTACEpigenetic Reader DomainProteolysis-targeting chimeraApoptosisBRD4degraderproteindegradationmidlinecarcinomaacutemyeloidleukemiaprostatemultiple myelomabreastcancerHL-60Raji THP-1cellInhibitorinhibitorinhibit

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PROTAC BRD4 Degrader-2
Cat. No.:
HY-133136
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