2. PROTAC Epigenetics
  3. Ligands for Target Protein for PROTAC Epigenetic Reader Domain
  4. BRD4 ligand 2

BRD4 ligand 2 is a BRD4 BD1 inhibitor with an IC50 of 46.4 nM. BRD4 ligand 2 inhibits the proliferation of lymphoma cells. BRD4 ligand 2 also serves as a target protein ligand for PROTACs, and is used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). BRD4 ligand 2 is applicable to research related to lymphoma.

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BRD4 ligand 2

BRD4 ligand 2 Chemical Structure

CAS No. : 2133902-07-3

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BRD4 ligand 2 Related Antibodies

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Brd BRPF1 BRPF2 BRPF3 BRD2 BRD3 BRD4 BRDT CECR2 BD1 BD2 BRD7 BRD9 BET BAZ

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Description

BRD4 ligand 2 is a BRD4 BD1 inhibitor with an IC50 of 46.4 nM. BRD4 ligand 2 inhibits the proliferation of lymphoma cells. BRD4 ligand 2 also serves as a target protein ligand for PROTACs, and is used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). BRD4 ligand 2 is applicable to research related to lymphoma[1].

IC50 & Target[1]

BRD4 BD1

46.4 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
CT26 IC50
35.98 μM
Compound: 13
Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 33862375]
HCT-116 IC50
3.341 μM
Compound: 14
Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 33214826]
HepG2 IC50
18.77 μM
Compound: 13
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 33862375]
THP-1 IC50
3.26 μM
Compound: 6
Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
[PMID: 31813613]
U-266 IC50
35.35 μM
Compound: 13
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 33862375]
In Vitro

BRD4 ligand 2 (Compound 6) potently inhibits BRD4 BD1 in the AlphaScreen biochemical assay, with an IC50 value of 46.4 nM[1].
BRD4 ligand 2 (72 h) inhibits the proliferation of human monocytic lymphoma THP-1 cells, with an IC50 of 3.26 μM after 72 h of incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 ligand 2 Related Antibodies
Molecular Weight

333.38

Formula

C20H19N3O2
CAS No.
SMILES

CC1=NOC(C)=C1C2=CC=C3C(C(NC(N3C)=O)C4=CC=CC=C4)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BRD4 ligand 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 ligand 22133902-07-3Ligands for Target Protein for PROTACEpigenetic Reader DomainTarget Protein-binding Moietymonocyte lymphomaBRD4 BD1c-MycTHP-1 human monocyte lymphoma cellsBRD4lymphoma cellsInhibitorinhibitorinhibit

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