2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Z7155
    2-Desfluoro fluconazole
    		Inhibitor
    2-Desfluoro fluconazole is an azole antifungal agent.
    2-Desfluoro fluconazole
  • HY-W028684
    2,4′-Dichloroacetanilide
    		Inhibitor 99.68%
    2,4′-Dichloroacetanilide is a fungistatic agent. 2,4′-Dichloroacetanilide inhibits T. asteroides with a MIC value of 6.25 μg/mL.
    2,4′-Dichloroacetanilide
  • HY-132191
    Pradimicin A
    		Inhibitor
    Pradimicin A is a potent antifungal agent with a minimum inhibitory concentration (MIC) of 4 μg/mL against Candida rugosa. Pradimicin A exhibits antiviral activity against SARS-CoV, human immunodeficiency virus (HIV) and other enveloped viruses. Pradimicin A exerts its fungicidal activity through a Ca2+-dependent mechanism, which induces fungal lysis. Pradimicin A can be used in research related to fungal infections, HIV infections and COVID-19.
    Pradimicin A
  • HY-157729
    1-Undecanoylglycerol
    		Inhibitor 98.0%
    1-Undecanoylglycerol is a monoacylglycerol with antibacterial activity, which can be used in food additives research.
    1-Undecanoylglycerol
  • HY-N0626R
    Sorbic acid (Standard)
    		Inhibitor
    Sorbic acid (Standard) is the analytical standard of Sorbic acid (HY-N0626). This product is intended for research and analytical applications. Sorbic acid is an antibacterial preservative effective against most molds, yeasts, and some bacterial species. Sorbic acid inhibits microbial growth. Sorbic acid suppresses the activity of intestinal microorganisms in zebrafish, alters the composition of intestinal flora, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α. Sorbic acid can be used in research on the prevention and treatment of mold, yeast, and bacterial infections.
    Sorbic acid (Standard)
  • HY-W040536
    DMDM hydantoin
    		Inhibitor
    DMDM hydantoin (Glydant) is an allergen and formaldehyde-releasing preservative. DMDM hydantoin releases formaldehyde under regulation by multiple factors and with enhanced release in alkaline environments. DMDM hydantoin induces allergic contact dermatitis via type-IV delayed hypersensitivity, either directly or through released formaldehyde. DMDM hydantoin is a broad-spectrum preservative that is effective against fungi, yeast, and gram-positive and gram-negative bacteria. DMDM hydantoin can be used in cosmetics industry production research (e.g., shampoos, hairsprays, and skincare products) and can be used for research on allergic contact dermatitis.
    DMDM hydantoin
  • HY-N0334
    (+)-Magnoflorine
    		Inhibitor
    (+)-Magnoflorine (α-Magnoflorine) is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine promotes Parkin/PINK1 -mediated mitochondrial autophagy, inhibits the activation of NLRP3/Caspase-1 pathway, regulates the intestinal microbiota, and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine inhibits JNK and TLR4/NF-κB signaling pathways, activates Sirt1/AMPK pathway, alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p, inhibits HMGB1/NF-κB pathway, and has anti-tumor activity. (+)-Magnoflorine also has significant antifungal activity.
    (+)-Magnoflorine
  • HY-119459R
    Fluopyram (Standard)
    		Inhibitor
    Fluopyram (Standard) is the analytical standard of Fluopyram (HY-119459). This product is intended for research and analytical applications. Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC50 values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic.
    Fluopyram (Standard)
  • HY-B2033S1
    Pyrimethanil-d5
    		99.89%
    Pyrimethanil-d5 is the deuterium labeled Pyrimethanil (HY-B2033). Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
    Pyrimethanil-d<sub>5</sub>
  • HY-119976S
    Boscalid-d4
    		Inhibitor
    Boscalid-d4 is the deuterium labeled Boscalid. Boscalid is a succinate dehydrogenase (SDHI) inhibitor with antifungal activity. Boscalid binds to the ubiquinone-binding site of fungal mitochondrial complex II, blocks ATP production and aerobic respiration, exhibits good control efficacy against a variety of plant fungal diseases including gray mold, sclerotinia rot and powdery mildew, and is widely used for disease control in agriculture. Boscalid induces apoptosis, altered lipid metabolism, mitochondrial dysfunction, respiratory impairment, oxidative stress, ROS accumulation and neurodevelopmental disorders in zebrafish. Boscalid reduces foraging ability, shortens median death time and causes chronic toxicity in exposed honeybees. Boscalid also possesses genotoxicity, cytotoxicity, elevated mitochondrial superoxide levels and early-stage apoptosis.
    Boscalid-d<sub>4</sub>
  • HY-107492
    Ethaboxam
    		Inhibitor 99.22%
    Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
    Ethaboxam
  • HY-W038767
    4-Methylbenzohydrazide
    		Inhibitor 99.89%
    4-Methylbenzohydrazide (p-ToluoylHYdrazine) (Compound 5) is an antibacterial agent. 4-Methylbenzohydrazide shows a pMIC value of 1.38 against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Aspergillus niger.
    4-Methylbenzohydrazide
  • HY-121414
    Phenazine oxide
    		Inhibitor 99.45%
    Phenazine oxide (Phenazine N-oxide) is a novel and potent fungicide, bactericide, and wood preservative.
    Phenazine oxide
  • HY-164620
    Antifungal agent 112
    		Inhibitor 99.50%
    Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candida albicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively.
    Antifungal agent 112
  • HY-N10895
    12-Hydroxyisobakuchiol
    		Inhibitor 98.74%
    12-Hydroxyisobakuchiol is a hemiterpenoid compound that can be isolated from the leaves of Psoralea glandulosa. 12-Hydroxyisobakuchiol inhibits mycelial growth of Botrytis cinerea in vitro. 12-Hydroxyisobakuchiol is applicable to research related to phytopathogenic fungal infections.
    12-Hydroxyisobakuchiol
  • HY-W712028
    α-Thujene
    α-Thujene is a natural fragrance with antifungal properties. It is extracted from eucalyptus trees. α-Thujene is recorded against Macrophomina phaseolina (85%) followed by Botrydiplodia theobromae (84%) which are better in comparison with standard Nystatin.
    α-Thujene
  • HY-N6726
    Fumonisin B3
    		99.51%
    Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma.
    Fumonisin B3
  • HY-W040305
    2,6-Dichloro-4-nitroaniline
    		Inhibitor ≥99.0%
    2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight.
    2,6-Dichloro-4-nitroaniline
  • HY-B2067R
    Cymoxanil (Standard)
    		Inhibitor
    Cymoxanil (Standard) is the analytical standard of Cymoxanil (HY-B2067). This product is intended for research and analytical applications. Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora.
    Cymoxanil (Standard)
  • HY-N3574
    Chloramultilide B
    		Inhibitor
    Chloramultilide B is a lindenane dimer that can be isolated from Chloranthus serratus. Chloramultilide B has inhibitory activities against Candida albicans and C.parapsilosis with a MIC value of 0.068 μM.
    Chloramultilide B
Cat. No. Product Name / Synonyms Application Reactivity