HDAC Inhibitor

HDAC Inhibitors (318):

Cat. No.	Product Name	Effect	Purity

HY-RS06065

Hdac11 Mouse Pre-designed siRNA Set A	Inhibitor
Hdac11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-118783

2-Hexyl-4-pentynoic acid	Inhibitor	98.0%
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), a Valproic acid (HY-10585) derivative, exhibits potential roles of HDAC inhibition (IC₅₀ = 13 μM) and HSP70 induction. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons. 2-Hexyl-4-pentynoic acid can be used for the study of breast carcinoma. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS06083

Hdac7 Mouse Pre-designed siRNA Set A	Inhibitor
Hdac7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-155329

GK718	Inhibitor
GK718 is a HDAC1/3 inhibitor (IC₅₀: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice.

HY-149474

HDAC-IN-63	Inhibitor
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC₅₀: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC₅₀: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML).

HY-17667

HDAC-IN-95	Inhibitor
HDAC-IN-95 (Compound 9) is a HDAC inhibitor. HDAC-IN-95 can be used for the study of non-small cell lung cancer (NSCLC).

HY-157215

HDAC-IN-66	Inhibitor
HDAC-IN-66 (compound 2F) is a selective HDAC inhibitor and Pomalidomide (HY-10984) derivative that potently inhibits hematological tumor cells.

HY-159112

AW01178	Inhibitor
AW01178 is a Class I HDAC inhibitor. AW01178 induces the upregulation of E-cadherin at both mRNA and protein levels and inhibits the EMT of breast cancer cells.

HY-149239

Topo II/HDAC-IN-2	Inhibitor
Topo II/HDAC-IN-2 (8d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-2 (8d) induces apoptosis.

HY-175857

HDAC-IN-92	Inhibitor
HDAC-IN-92 is a pan-HDAC inhibitor with an IC₅₀ of 12.58 µM in A2780 cells. HDAC-IN-92 demonstrates broad-spectrum, notable cytotoxic activity against a range of human cancer cell lines, including ovarian, liver, and breast carcinomas. HDAC-IN-92 causes apoptosis and demonstrates a notable decrease in tumor cell colony formation. HDAC-IN-92 inhibits the formation of blood vessels in the chick chorioallantoic membrane (CAM). HDAC-IN-92 exhibits anti-tumor effect in a 4T1 tumor-bearing mouse model. HDAC-IN-92 can be used for research targeting solid tumor.

HY-10585AG

Valproic acid sodium (GMP)	Inhibitor
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

HY-155392

Mz325	Inhibitor	98.10%
Mz325 is a dual inhibitor of HDAC and Sirt2, with the IC₅₀ of 9.7 μM to Sirt2, that play an important role in pathogenesis of cancer and neurodegeneration.

HY-RS06086

Hdac8 Mouse Pre-designed siRNA Set A	Inhibitor
Hdac8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hdac8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-W794759

Valproic acid magnesium	Inhibitor
Valproic acid magnesium (Magnesium valproate) is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM. Valproic acid magnesium inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid magnesium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid magnesium is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.

HY-158205

HPO-DAEE	Inhibitor
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways.

HY-156003

HDAC-IN-64	Inhibitor
HDAC-IN-64 (Compound 13) is a HDAC inhibitor. HDAC-IN-64 inhibits HDAC4/5/6/7/9 with IC₅₀s of 24, 45, 85, 31, 37 nM. HDAC-IN-64 has anti-proliferative activity and anti-migration properties on prostate cancer (PCA) cells. HDAC-IN-64 inhibits LNCaP and RWPE-1 cell growth with GI₅₀ of 0.32 and 1.1 μM respectively.

HY-162868

c-Met/HDAC-IN-4	Inhibitor
c-Met/HDAC-IN-4 is a dual inhibitor of c-Met/HDAC. The IC₅₀ value of c-Met/HDAC-IN-4 for c-Met is 28.92 nM. c-Met/HDAC-IN-4 can induce G₀/G₁ phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells, and it inhibits the proliferation and invasion of breast cancer cell lines.

HY-155890

Fimepinostat mesylate	Inhibitor
Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-185341

PTERi	Inhibitor	98.04%
PTERi is a selective inhibitor of PTER with selectivity towards HDACs. PTERi increases the level of N-acetyltaurine in both lean and obese mice, and reduces food intake in obese mice. PTERi can be used in the research of obesity.

HY-RS06075

Hdac4 Rat Pre-designed siRNA Set A	Inhibitor
Hdac4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hdac4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Name
Email *

	Sorry, but the email address you supplied was invalid.