2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC8-IN-7

HDAC8-IN-7 (H7E), a HDAC8 inhibitor, exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress. HDAC8-IN-7 alleviates functional and structural defects within the inner retina.

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HDAC8-IN-7 Estructura química

HDAC8-IN-7 Estructura química

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HDAC8-IN-7 Related Antibodies

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Descripciòn

HDAC8-IN-7 (H7E), a HDAC8 inhibitor, exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress. HDAC8-IN-7 alleviates functional and structural defects within the inner retina[1].
Peso molecular

344.36

Fòrmula

C18H20N2O5
Unlabeled Cas

SMILES

COC1=CC=C(/C=C/C(NO)=O)C(NC2=CC=C(OC)C(OC)=C2)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    H7E (30?mg/kg) dissolved in a cosolvent (EtOH: cremophor: normal saline = 1: 1: 8)[1].

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Pureza y Documentación
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HDAC8-IN-7 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC8-IN-7HDACHistone deacetylasesHDAC8oxidative stressRGCInhibitorinhibitorinhibit

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