HDAC-IN-63
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively). HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 2920046-95-1
- Formula: C25H26Cl2N6O3
- Molecular Weight:529.42
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
0.844 and 30.0 nM for FLT3 and HDAC1[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
0.142 μM
Compound: 63
|
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
|
[PMID: 37659198] |
| MOLM-13 | IC50 |
142 nM
Compound: 21
|
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability incubated for 48 hr by CellTiter-Glo assay
|
[PMID: 39094274] |
| MV4-11 | IC50 |
0.092 μM
Compound: 63
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
|
[PMID: 37659198] |
| MV4-11 | IC50 |
92 nM
Compound: 21
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell growth
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell growth
|
[PMID: 39094274] |
| U-937 | IC50 |
4.538 μM
Compound: 63
|
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability after 72 hrs by CellTiterGlo assay
|
[PMID: 37659198] |
Chemical Information
-
CAS No. 2920046-95-1
-
Molecular Weight 529.42
-
Formula C25H26Cl2N6O3
-
SMILES
ClC1=CC=CC(Cl)=C1CN(C=N2)C3=C2C=CC(C4=CC(NC(CCCCCCC(NO)=O)=O)=NN4)=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)