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Cat. No.: HY-156091

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PI3Kα/HDAC6-IN-1

PI3Kα/HDAC6-IN-1 (compound 21j) is a dual PI3Kα/HDAC6 inhibitor with IC₅₀ of 2.9 and 26 nM, respectively. PI3Kα/HDAC6-IN-1 also inhibits AKT(Ser473) phosphorylation and induces the accumulation of acetylated α-tubulin without affecting acetylated histones H3 and H4. PI3Kα/HDAC6-IN-1 efficiently inhibits L-363 cell line (IC₅₀=0.17 μM) and has good anti-cancer activity.

For research use only. We do not sell to patients.

CAS No.: 3007565-26-3
Formula: C₂₇H₃₀F₃N₇O₆S₂
Molecular Weight:669.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PI3Kα/HDAC6-IN-1 Chemical Structure

CAS No.: 3007565-26-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 2.9 nM (PI3Kα), 26 nM (HDAC6)^[1]

All PI3K Isoforms :

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L-363	IC₅₀	0.17 μM Compound: 21j	Antiproliferative activity against human L-363 cells Antiproliferative activity against human L-363 cells	[PMID: 37652098]
MCF7	IC₅₀	1.23 μM Compound: 21j	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 37652098]
T47D	IC₅₀	>10 μM Compound: 21j	Antiproliferative activity against human T47D cells Antiproliferative activity against human T47D cells	[PMID: 37652098]

Chemical Information

CAS No. 3007565-26-3
Molecular Weight 669.70
Formula C₂₇H₃₀F₃N₇O₆S₂
SMILES

CC(C(F)(F)F)(C)C1=CC(C2=C(C)N=C(NC(N3C[C@H](NS(=O)(CC4=CC=C(C(NO)=O)C=C4)=O)C[C@H]3C(N)=O)=O)S2)=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Discovery of (S)-N1-(thiazol-2-yl) pyrrolidine-1,2-dicarboxamide derivatives targeting PI3Ka/HDAC6 for the treatment of cancer. Bioorg Med Chem Lett. 2023 Oct 1;94:129462.. . [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PI3Kα/HDAC6-IN-1

All PI3K Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PI3Kα/HDAC6-IN-1 Related Classifications

HY-156091 Related Classifications