Insulin Receptor
Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. The insulin receptor exists in two isoforms, IR-A and IR-B, expressed in different relative abundance in the various organs and tissues. The two IR isoforms have similar binding affinity for insulin but different affinity for insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B.
The insulin receptor has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.
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Insulin Receptor Inhibitors
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Insulin Receptor Agonists
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Insulin Receptor Antagonists
(12)
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Insulin Receptor Activators
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Insulin Receptor Modulators
(5)
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Insulin Receptor Inducer
(1)
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Insulin Receptor Degrader
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Insulin Receptor Substrates
(3)
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Insulin Receptor Ligand
(1)
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Insulin Receptor (INSR) Proteins
(5)
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INSR/CD220 Proteins
(7)
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Insulin Receptor Related Products (204)
Related Products (204)
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Recombinant Proteins (8)
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Antibodies (8)
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NVP-TAE 226 (Standard)
0 ImagesSynonyms: TAE226 (Standard)NVP-TAE 226 (Standard) is the analytical standard of NVP-TAE 226. This product is intended for research and analytical applications. NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively.
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Ceritinib (Standard)
0 ImagesSynonyms: LDK378 (Standard)Ceritinib (Standard) is the analytical standard of Ceritinib (HY-15656). This product is intended for research and analytical applications. Ceritinib is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency.
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Linsitinib (Standard)
0 ImagesSynonyms: OSI-906 (Standard)Linsitinib (Standard) is the analytical standard of Linsitinib. This product is intended for research and analytical applications. Linsitinib (OSI-906) is a potent, selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC50s of 35 and 75 nM, respectively.
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Mesoxalate
0 ImagesMesoxalate (Ketomalonic acid) is an orally active antidiabetic agent. Mesoxalate increases pancreatic insulin content. Mesoxalate reduces dietary hyperglycemia. Mesoxalate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Mesoxalate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Mesoxalate can be used in diabetes-related research.
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(2S,3R,4S)-4-Hydroxyisoleucine (Standard)
0 ImagesSynonyms: (2S,3R,4S)-4-Hydroxy-L-isoleucine (Standard)(2S,3R,4S)-4-Hydroxyisoleucine (Standard) is the analytical standard of (2S,3R,4S)-4-Hydroxyisoleucine (HY-W010271). This product is intended for research and analytical applications. (2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S)-4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S)-4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity.
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Glicetanile
0 ImagesCat. No.: HY-163652CAS No.: 24455-58-1Glicetanile is an orally active hypoglycemic agent, that stimulates the release of insulin from pancreatic beta cells, and lowers the blood sugar. Glicetanile exhibits potential in ameliorating the type 2 diabetes.
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hsa-let-7f-5p mimic
0 ImagesCat. No.: HY-R04639hsa-let-7f-5p mimic is a synthetic double-stranded microRNA used to overexpress mature let-7f-5p in cells for mimicking its tumor-suppressive function. hsa-let-7f-5p mimic is predicted to inhibit the expression of SLC5A5 and INSR. hsa-let-7f-5p mimic can be applied to research related to thyroid cancer and pancreatic ductal adenocarcinoma.
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Anti-CD220/Insulin Receptor Antibody (IR 83-22)
0 ImagesCat. No.: HY-P990867Anti-CD220/Insulin Receptor Antibody (IR 83-22) is an anti-human CD220/Insulin Receptor IgG1 monoclonal antibody. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can block Akt overactivation caused by Trip13 deficiency. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can be used for research on cancer such as hepatocellular carcinoma (HCC). Anti-CD220/Insulin Receptor Antibody (IR 83-22) often used in western blotting. The recommend isotype control of Anti-CD220/Insulin Receptor Antibody (IR 83-22): Mouse IgG1 kappa, Isotype Control (HY-P99977).
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PP185
0 ImagesCat. No.: HY-183840CAS No.: 851176-40-4PP185 is a insulin receptor kinase substrate. PP185 undergoes rapid tyrosine phosphorylation, with activity dependent on divalent cations and inhibited by insulin receptor kinase domain antibodies. PP185 can be used for the research of neuroblastoma.
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NT157 (Standard)
0 ImagesCat. No.: HY-100037RCAS No.: 1384426-12-3Synonyms: Tyrphostin NT157 (Standard)NT157 (Standard) is the analytical standard of NT157 (HY-100037). This product is intended for research and analytical applications. NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway.
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CEP-14083
0 ImagesCat. No.: HY-14243CAS No.: 856692-39-2CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC50 value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma.
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CI-624
0 ImagesCat. No.: HY-W516943CAS No.: 700-07-2CI-624 decrease secretion volumes and outputs of hydrogen, sodium and potassium ions and of pepsin. CI-624 can be used in the research of cancer and autoimmune diseases.
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GSK1904529A (Standard)
0 ImagesCat. No.: HY-10524RCAS No.: 1089283-49-7GSK1904529A (Standard) is the analytical standard of GSK1904529A (HY-10524). This product is intended for research and analytical applications. GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity.
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XOMA 129
0 ImagesCat. No.: HY-P991291XOMA 129 is a human monoclonal antibody targeting INSR. XOMA 129 is an insulin receptor (IR) antagonist that inhibits the drop in blood glucose. XOMA 129 can be used in the study of hypoglycemia .
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Somatostatin RC-102
0 ImagesCat. No.: HY-P2167CAS No.: 99685-66-2Somatostatin RC-102 is an octapeptide analog of Somatostatin. Somatostatin RC-102 inhibits the release of growth hormone and insulin. Somatostatin RC-102 enhances the inhibition of cell migration by increasing the production or activity of LMIF, but exerts no effect on cell migration in the absence of exposure to cardiac antigens or phytohemagglutinin. Somatostatin RC-102 inhibits gastric acid secretion. Somatostatin RC-102 can be used in the research of heart diseases.
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Insulin B (20-30)
0 ImagesCat. No.: HY-P2437CAS No.: 91921-56-1
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BMS-536924 (Standard)
0 ImagesCat. No.: HY-10262RCAS No.: 468740-43-4BMS-536924 (Standard) is the analytical standard of BMS-536924 (HY-10262). This product is intended for research and analytical applications. BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity.
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Monosialoganglioside GM3 (bovine)
0 ImagesCat. No.: HY-W342441CAS No.: 54827-14-4Monosialoganglioside GM3 (bovine) is a monosialoganglioside and an inhibitor of VEGFR2 and Akt. At a concentration of 20 μM, Monosialoganglioside GM3 inhibits angiogenesis and reduces the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by inhibiting VEGFR2 and Akt phosphorylation. Ganglioside GM3 also inhibits ferroptosis, providing protective effects during the formation of abdominal aortic aneurysms. Additionally, Monosialoganglioside GM3 (bovine) acts as an inhibitor of insulin signaling, inducing the dissociation of the insulin receptor (IR)-Caveolin-1 complex from lipid microdomains and causing insulin resistance in adipocytes. Monosialoganglioside GM3 (bovine) can be used in cancer and metabolic disease research.
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Ceritinib dihydrochloride (Standard)
0 ImagesSynonyms: LDK378 dihydrochloride (Standard)Ceritinib (LDK378) dihydrochloride (Standard) is the analytical standard of Ceritinib dihydrochloride (HY-15656A). This product is intended for research and analytical applications. Ceritinib dihydrochloride is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency.
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MSDC 0160 (Standard)
0 ImagesCat. No.: HY-100550RCAS No.: 146062-49-9Synonyms: Mitoglitazone (Standard); CAY10415 (Standard)MSDC 0160 (Standard) is the analytical standard of MSDC 0160 (HY-100550). This product is intended for research and analytical applications. MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimer′s disease.
