2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. PAK
  5. PAK Degrader

PAK Degrader

PAK Isoform Comparison

PAK Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-148821
    BJG-05-039
    		Degrader
    BJG-05-039 is a PAK1-selective degrader consisting of NVS-PAK1-1 (HY-100519) conjugated to Lenalidomide (HY-A0003). BJG-05-039 induces selective degradation of PAK1. BJG-05-039 inhibits phosphorylation of MEK S298, as well as inhibiting phosphorylation of ERK. BJG-05-039 has an anti-proliferative effect on PAK1-dependent cell lines.
  • HY-174247
    CPS-021
    		Degrader
    CPS-021 is a selective PAK4 PROTAC degrader with a DC50 of 50 nM. CPS-021 has potent antimigratory and invasive activity and significantly suppresses the invasion and metastasis of tumor cells in A549-luc lung metastasis mice model. Pink: PAK4 ligand (HY-174822); Blue: CRBN ligase ligand (HY-10984); Black: linker
  • HY-174822
    PAK4-IN-6
    		Degrader
    PAK4-IN-6 is a selective degrader of PAK4. PAK4-IN-6 can be used to synthesize PROTACs such as CPS-021 (HY-174247).