2. Signaling Pathways
  3. Anti-infection
  4. RSV

RSV

Respiratory syncytial virus

RSV

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RSV (Respiratory syncytial virus) is a leading cause of acute respiratory infections. RSV can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination. There is a single RSV serotype with two major antigenic subgroups, A and B.

RSV is a non-segmented negative-sense single-stranded enveloped RNA virus that belongs to the family of Paramyxoviridae, genus Pneumovirus, subfamily Pneumovirinae. Its 10 genes encode 11 proteins since two overlapping open reading frames in the M2 mRNA yield two distinct matrix proteins, M2-1 and M2-2. The viral envelope contains three proteins, the G glycoprotein, the fusion (F) glycoprotein, and the small hydrophobic (SH) protein. The RSV virus comprises five other structural proteins, the large (L) protein, nucleocapsid (N), phosphoprotein (P), matrix (M), and M2-1, and two non-structural proteins (NS1 and NS2).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15455S1
    Roflumilast-d4 N-Oxide
    		Inhibitor 98.13%
    Roflumilast-d4 N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
    Roflumilast-d<sub>4</sub> N-Oxide
  • HY-19874
    RFI-641
    		Inhibitor
    RFI-641 is a selective inhibitor of the respiratory syncytial virus (RSV), with an IC50 of 50 nM. RFI-641 inhibit binding and fusion of enveloped virus via interaction with the viral fusion protein.
    RFI-641
  • HY-P991157
    Retavibart
    Retavibart is a human respiratory syncytial virus (RSV) fusion glycoprotein F. Retavibart can be used for antiviral research. Isotype control: Human IgG1 kappa.
    Retavibart
  • HY-142009
    Antiviral agent 10
    		Inhibitor
    Antiviral agent 10 is an anti-viral agent that can inhibit respiratory syncytial virus (RSV).
    Antiviral agent 10
  • HY-100285
    RD3-0028
    		Inhibitor
    RD3-0028 is a potent and selective inhibitor of RSV replication with an EC50 of 4.5 μM.
    RD3-0028
  • HY-126033
    Sophoranol
    		Inhibitor
    Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL.
    Sophoranol
  • HY-148308
    hRSV-IN-1
    		Inhibitor
    hRSV-IN-1 is an inhibitor of respiratory syncytial virus (hRSV).
    hRSV-IN-1
  • HY-154966
    RSV L-protein-IN-3
    		Inhibitor
    RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434).
    RSV L-protein-IN-3
  • HY-178151
    CGR-50
    		Inhibitor
    CGR-50 is a potent RSV fusion glycoprotein (F protein) inhibitor (EC50 = 32.6 nM against RSV A2 in HEp-2 cells). CGR-50 blocks RSV entry by binding to the F protein and inhibiting membrane fusion. CGR-50 can be used for RSV infection research.
    CGR-50
  • HY-W779404
    Ribavirin-13C2
    Ribavirin-13C2 (Ribasphere-13C2) is the 13C-labeled Ribavirin (HY-B0434). Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
    Ribavirin-13</sup>C<sub>2</sub>
  • HY-W320523
    ALizarin complexone dihydrate
    		Inhibitor
    ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens.
    ALizarin complexone dihydrate
  • HY-163567
    RSV-IN-10
    		Inhibitor
    RSV-IN-10 (compound 6a) shows antiviral activity against RSV with the IC50 of 4 μM. RSV-IN-10 can be used for study of respiratory infection.
    RSV-IN-10
  • HY-15455S2
    Roflumilast-d3
    		Inhibitor
    Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
    Roflumilast-d<sub>3</sub>
  • HY-P991499
    EVO-46120
    		Inhibitor
    EVO-46120 is a human monoclonal antibody (mAb) targeting F, Fusion glycoprotein F0. EVO-46120 can be used in respiratory syncytial virus (RSV) and metapneumovirus infections research.
    EVO-46120
  • HY-143495
    RSV-IN-3
    		Inhibitor
    RSV-IN-3 (Compound 1) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-3 shows anti-RSV activity (EC50 = 32.70 μM).
    RSV-IN-3
  • HY-111296
    YM 53403
    		Inhibitor
    YM 53403 is an anti-respiratory syncytial virus (RSV) agent, with an EC50 of 0.20 μM. YM 53403 potently inhibits the replication of RSV strains belonging to both A and B subgroups.
    YM 53403
  • HY-143494
    RSV/IAV-IN-3
    		Inhibitor
    RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC50 values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC50 values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC50 of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage.
    RSV/IAV-IN-3
  • HY-B0434S
    Ribavirin-13C5
    		Inhibitor
    Ribavirin-13C5 is the 13C-labeled Ribavirin. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.
    Ribavirin-<sup>13</sup>C<sub>5</sub>
  • HY-B0434G
    Ribavirin (GMP)
    		Inhibitor
    Ribavirin (GMP) is Ribavirin (HY-B0434) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
    Ribavirin (GMP)
  • HY-N6771R
    Cyclopiazonic acid (Standard)
    		Inhibitor
    Ancitabine (hydrochloride) (Standard) is the analytical standard of Ancitabine (hydrochloride). This product is intended for research and analytical applications. 0
    Cyclopiazonic acid (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity