Ras
Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.
Ras Isoform Specific Products
All Product Categories
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Ras Related Products (712)
Related Products (712)
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Antibodies (36)
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Ras Isoform Comparison
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KRAS inhibitor-17
0 ImagesCat. No.: HY-146475CAS No.: 2230873-65-9KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers.
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Tyrphostin 8
0 ImagesTyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM).
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SOS1-IN-6
0 ImagesCat. No.: HY-144210CAS No.: 2751718-88-2SOS1-IN-6 (compound 33-P1) is a potent SOS1 inhibitor with IC50s of 14.9 and 73.3 nM for SOS1-G12D and SOS1-G12V, respectively.
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Rapaprutug
0 ImagesCat. No.: HY-P991156CAS No.: 2994192-38-8Rapaprutug is a monoclonal antibody targeting human KARS1 (lysyl-tRNA synthetase 1). Rapaprutug blocks the relevant inflammatory signaling pathways in which KARS1 is involved, reducing the production and release of inflammatory factors. Rapaprutug is promising for research of inflammatory diseases.
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KRAS G12D-IN-27
0 ImagesCat. No.: HY-171581CAS No.: 2938179-13-4
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KRAS G12C-IN-78
0 ImagesCat. No.: HY-181965CAS No.: 3023465-20-2KRAS G12C-IN-78 is a selective SWII-binding KRASG12C dual inhibitor targeting both inactive and active states. KRAS G12C-IN-78 rapidly inhibits ERK1/2 phosphorylation, induces covalent adduct formation with endogenous KRASG12C, suppresses MAPK pathway gene expression, and inhibits cellular proliferation in KRASG12C mutant cells. KRAS G12C-IN-78 can be used for the research of KRASG12C mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cell lung cancer.
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KRAS G12C inhibitor 45
0 ImagesCat. No.: HY-142947CAS No.: 2670380-74-0KRAS G12C inhibitor 45 (compound 78) is a potent KRAS G12C inhibitor.
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KRas G12C inhibitor 2
0 ImagesCat. No.: HY-112492CAS No.: 2206735-61-5KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1.
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FTS-MOM
0 ImagesCat. No.: HY-186198CAS No.: 1092521-71-5Synonyms: Salirasib methoxymethyl ester
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KRAS inhibitor-40
0 ImagesCat. No.: HY-168442CAS No.: 3059496-56-6KRAS inhibitor-40 (Compound 41) is a KRAS inhibitor that interferes with the KRAS G12C-BRAF complex. KRAS inhibitor-40 inhibits the ERK phosphorylation of KRAS downstream signaling pathway. KRAS inhibitor-40 can inhibit the proliferation of tumor cells with different KRAS mutation types and has antitumor activity.
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KRAS inhibitor-21
0 ImagesCat. No.: HY-151288CAS No.: 2411786-50-8KRAS inhibitor-21 (22b) is a KRAS G12C inhibitor with an IC50 value of <0.01 μM. KRAS inhibitor-21 can be used in cancer research.
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KRAS inhibitor-34
0 ImagesCat. No.: HY-162974CAS No.: 3030078-43-1KRAS inhibitor-34 (compound 27) is a KRAS inhibitor, with IC50 of 6.4 nM. KRAS inhibitor-34 can be used in tumor research.
