Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
(634)
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Nav1.1
(12)
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Nav1.2
(19)
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Nav1.3
(17)
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Nav1.4
(16)
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Nav1.5
(28)
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Nav1.6
(14)
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Nav1.7
(64)
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Nav1.8
(43)
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Nav1.9
(3)
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All Product Categories
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Sodium Channel Inhibitors
(638)
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Sodium Channel Agonists
(10)
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Sodium Channel Antagonists
(29)
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Sodium Channel Activators
(36)
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Sodium Channel Modulators
(31)
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Sodium Channel Controls
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Sodium Channel Ligands
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Sodium Channel Related Products (821)
Related Products (821)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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DA-0218
0 ImagesCat. No.: HY-182710CAS No.: 1081317-31-8DA-0218 is a Nav1.7 inhibitor. DA-0218 exerts state-dependent inhibitory effects. DA-0218 alleviates formalin-induced inflammatory pain behavior and Paclitaxel-induced mechanical hyperalgesia in mice. DA-0218 inhibits Histamine-induced acute pruritus and lymphoma-induced chronic pruritus in mice. DA-0218 can be used in research related to inflammatory pain, neuropathic pain, acute pruritus and chronic pruritus.
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Oxcarbazepine-d10
0 ImagesCat. No.: HY-B0114S3CAS No.: 2749432-28-6Synonyms: GP 47680-d10Oxcarbazepine-d10 (GP 47680-d10) is deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
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Riluzole hydrochloride (Standard)
0 ImagesSynonyms: PK 26124 hydrochloride (Standard)Riluzole hydrochloride (Standard) is the analytical standard of Riluzole hydrochloride. This product is intended for research and analytical applications. Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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Oxcarbazepine-d4
0 ImagesCat. No.: HY-B0114SCAS No.: 1020719-71-4Synonyms: GP 47680-d4Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
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Dexnafenodone
0 ImagesCat. No.: HY-105521CAS No.: 92629-87-3Synonyms: (S)-Nafenodone free base; LU-43706 free baseDexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression.
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Riluzole-13C6
0 ImagesCat. No.: HY-B0211S1Synonyms: PK 26124-13C6Riluzole-13C6 (PK 26124-13C6) is 13C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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DPI 201-106 (Standard)
0 ImagesCat. No.: HY-19666RCAS No.: 97730-95-5Synonyms: SDZ 201106 (Standard)DPI 201-106 (Standard) is the analytical standard of DPI 201-106. This product is intended for research and analytical applications. DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect.
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Ropivacaine hydrochloride monohydrate (Standard)
0 ImagesRopivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Ropivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo.
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Recainam hydrochloride
0 ImagesCat. No.: HY-105454ACAS No.: 74752-07-1Synonyms: Wy-42362 hydrochlorideRecainam (Wy-42362) hydrochloride is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam hydrochloride elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam hydrochloride can be used for the research of arrhythmias.
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Eslicarbazepine-d4
0 ImagesCat. No.: HY-114703S1Synonyms: BIA 2-194-d4Eslicarbazepine-d4 (BIA 2-194-d4) is deuterium labeled Eslicarbazepine. Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
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Permethrin-d6
0 ImagesCat. No.: HY-W774926CAS No.: 82523-59-9Synonyms: NRDC-143-d6Permethrin-d6 (NRDC-143-d6) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).
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(+)-Kavain (Standard)
0 Images(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.
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NAV 26
0 ImagesNAV 26 (Compound 26) is a selective NaV1.7 inhibitor with an IC50 of 0.37 μM. NAV 26 is applicable for pain-related research.
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A-803467 (Standard)
0 ImagesCat. No.: HY-11079RCAS No.: 944261-79-4A-803467 (Standard) is the analytical standard of A-803467 (HY-11079). This product is intended for research and analytical applications. A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter.
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Dexpramipexole-d3 dihydrochloride
0 ImagesCat. No.: HY-17355BSCAS No.: 1432230-09-5Synonyms: (R)-Pramipexole-d3 dihydrochloride; R-(+)-Pramipexole-d3 dihydrochloride; KNS-760704-d3 dihydrochlorideDexpramipexole-d3 ((R)-Pramipexole-d3) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.
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Amiloride hydrochloride dihydrate (Standard)
0 ImagesSynonyms: MK-870 hydrochloride dihydrate (Standard)Amiloride hydrochloride dihydrate (Standard) is the analytical standard of Amiloride hydrochloride dihydrate. This product is intended for research and analytical applications. Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.
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Gonyautoxin II
0 ImagesCat. No.: HY-19605CAS No.: 60508-89-6Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease.
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Dibucaine (Standard)
0 ImagesDibucaine (Standard) is the analytical standard of Dibucaine. This product is intended for research and analytical applications. Dibucaine (Cinchocaine) is a sodium channel inhibitor. Dibucaine is a potent SChE inhibitor.
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Zorevunersen sodium scrambled negative control
0 ImagesCat. No.: HY-148410DZorevunersen sodium scrambled negative control is the sequence scrambled negative control of Zorevunersen sodium.
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Disopyramide (Standard)
0 ImagesDisopyramide (Standard) is the analytical standard of Disopyramide. This product is intended for research and analytical applications. Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action.
