Vasopressin Receptor
The neurohypophysial hormone arginine vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of vasopressin receptors, designated V1a, V1b (or V3), and V2. They all belong to the large rhodopsin-like G-protein-coupled receptor family.
The V1a receptor is expressed in both neuronal and non-neuronal tissues including the heart and elicits a variety of physiological effects including cell contraction and proliferation, stimulation of hepatic glycogenolysis, platelet aggregation and coagulation factor release. The V1b receptor subtype is found predominantly in the pituitary gland where it stimulates adrenocorticotropic hormone release. Both the V1a and V1b AVP receptors act through a G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) to activate phospholipase C-β, and, thus enhance cellular IP3 and calcium levels. By contrast, the V2 receptor subtype is localized predominantly to the kidney where it mediates the anti-diuretic effects of AVP through the heterotrimeric G protein Gs and activation of adenylyl cyclase.
Vasopressin Receptor Isoform Specific Products
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Vasopressin Receptor Inhibitors
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Vasopressin Receptor Agonists
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Vasopressin Receptor Antagonists
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Vasopressin Receptor Modulator
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Vasopressin Receptor Ligand
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Vasopressin Receptor Related Products (127)
Related Products (127)
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Vasopressin Receptor Isoform Comparison
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D[LEU4,LYS8]-VP
![D[LEU4,LYS8]-VP](https://file.medchemexpress.com/product_pic/hy-p1163.gif "Click to View D[LEU4,LYS8]-VP Product Detail")
0 ImagesCat. No.: HY-P1163CAS No.: 42061-33-6D[LEU4,LYS8]-VP is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities.
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Atosiban-d5 TFA
0 ImagesCat. No.: HY-17572SSynonyms: RW22164-d5 TFA; RWJ22164-d5 TFAAtosiban-d5 TFA (RW22164-d5 TFA) is the deuterium labeled Atosiban TFA. Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.
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VA-111913
0 ImagesCat. No.: HY-111225CAS No.: 877856-17-2Synonyms: VT-913VA-111913 (VT-913) is a vasopressin receptor V1A antagonist (Ki = 1.74 nM). VA-111913 reduces uterine contractions and improves uterine blood flow by inhibiting vasopressin, thereby alleviating dysmenorrhea. VA-111913 can be used for research on menstrual pain.
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XYDC2050
0 ImagesCat. No.: HY-180142XYDC2050 (Compound 29) is a selective vasopressin V2 receptor (V2R) antagonist with an IC50 of 27 nM and a Ki of 2.8 nM. XYDC2050 shows a Ki of 420.7 nM (SI = 162 fold) for V1R. XYDC2050 can inhibit Vasopressin (HY-B1811)-induced intracellular cyclic adenosine monophosphate (cAMP) accumulation with an IC50 of 12 nM. XYDC2050 can inhibit the growth of renal cysts, reduce the ratio of kidney weight to body weight and decrease the area of cysts and the cystic index. XYDC2050 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
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Tolmesoxide
0 ImagesCat. No.: HY-107037CAS No.: 38452-29-8Synonyms: RX71107Tolmesoxide (RX71107) is a peripheral vascular dilator with blood pressure lowering activity. Tolmesoxide has shown direct vasodilation in the human forearm arterial bed and dorsal hand vein. Tolmesoxide can dose-dependently increase blood flow in the forearm and produce dilation during contraction of the dorsal hand veins. Tolmesoxide can be used to study high blood pressure and angina.
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Ribuvaptan
0 ImagesCat. No.: HY-16783CAS No.: 1245620-47-6Ribuvaptan is a vasopressin receptor antagonist. Ribuvaptan can be used for the study of Heart failure.
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[Lys8] Vasopressin Desglycinamide
![[Lys8] Vasopressin Desglycinamide](https://file.medchemexpress.com/product_pic/hy-p4009.gif "Click to View [Lys8] Vasopressin Desglycinamide Product Detail")
0 ImagesCat. No.: HY-P4009CAS No.: 32215-99-9[Lys8] Vasopressin Desglycinamide is a vasopressin analog, used for the maintenance of active and passive avoidance behavior. [Lys8] Vasopressin Desglycinamide facilitates memory consolidation processes.
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V1b Receptor antagonist-1
0 ImagesCat. No.: HY-178573CAS No.: 1056550-56-1V1b receptor antagonist-1 is a potent, selective and brain-penetrant vasopressin 1b (V1b) receptor antagonist. V1b receptor antagonist-1 exhibits anti-depressant activity. V1b receptor antagonist-1 can be used for the research of neurological disease, such as depression.
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Elsovaptan
0 ImagesCat. No.: HY-172427CAS No.: 2296801-25-5Elsovaptan is the antagonist for vasopressin receptor that can be used in researchs of Alzheimer disease.
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Mozavaptan-d6
0 ImagesCat. No.: HY-18346SCAS No.: 2750534-83-7Synonyms: OPC-31260-d6Mozavaptan-d6 (OPC-31260-d6) is the deuterium labeled Mozavaptan. Mozavaptan (OPC-31260) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment.
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ML389
0 ImagesCat. No.: HY-124275CAS No.: 1622294-25-0ML389 is a highly selective vasopressin 1a (V1a) receptor antagonist (IC50=40 nM). ML389 is promising for research of central nervous system disorders such as anxiety, depression, and post-traumatic stress disorder (PTSD).
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Pecavaptan
0 ImagesCat. No.: HY-109133CAS No.: 1914998-56-3Synonyms: BAY 1753011Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
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Imidafenacin hydrochloride
0 ImagesCat. No.: HY-B0662ACAS No.: 893421-54-0Synonyms: KRP-197 hydrochloride; ONO-8025 hydrochlorideImidafenacin (KRP-197; ONO-8025) hydrochloride is an orally active inhibitor of muscarinic (mAChR) M1 and M3 receptors. Imidafenacin hydrochloride potently inhibits bladder contraction in vivo and exerts an antidiuretic effect by enhancing the signaling pathway of vasopressin (antidiuretic hormone). Imidafenacin hydrochloride can be used in research related to overactive bladder.
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[Deamino-Pen1,Val4,D-Arg8]-vasopressin
![[Deamino-Pen1,Val4,D-Arg8]-vasopressin](https://file.medchemexpress.com/product_pic/hy-p10046.gif "Click to View [Deamino-Pen1,Val4,D-Arg8]-vasopressin Product Detail")
0 ImagesCat. No.: HY-P10046CAS No.: 64158-84-5[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.
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Val9-Oxytocin
0 ImagesCat. No.: HY-P4994CAS No.: 1021701-88-1Val9-Oxytocin is a full antagonist of vasopressin (V1a) receptor. Val9-Oxytocin is an analog of Oxytocin (HY-17571A) in which changing Gly9 to Val9.
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Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin
0 ImagesCat. No.: HY-P4010CAS No.: 136105-89-0Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin, a synthetic analog of vasopressin (AVP), is a weak agonist at antidiuretic receptor. However, Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin is a potent agonist at pituitary corticotrope receptor.
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Fidinvaptan
0 ImagesCat. No.: HY-187869CAS No.: 2826938-65-0Fidinvaptan is a Vasopressin receptor antagonist.
