Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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(Rac)-Tenofovir
0 ImagesCat. No.: HY-13910CCAS No.: 107021-12-5Synonyms: (Rac)-GS 1278; (Rac)-PMPA
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SQ 31906 free base
0 ImagesCat. No.: HY-182475CAS No.: 81131-74-0SQ 31906 free base is the 3α-hydroxy isomer and metabolite of Pravastatin (HY-B0165). SQ 31906 free base forms via non-enzymatic reaction under acidic conditions. Pravastatin is used in hypercholesterolemia research.
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(Z)-Pseudoginsenoside Rh2
0 ImagesCat. No.: HY-125825ACAS No.: 1636114-55-0(Z)-Pseudoginsenoside Rh2 is the (Z) isoform of Pseudoginsenoside Rh2 (HY-125825), which is synthesized from Ginsenoside Rh2, possesses anti-cancer activitied.
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(R,R)-MMP-1-IN-1
0 ImagesCat. No.: HY-152092APurity: 98.00%(R,R)-MMP-1-IN-1 is the R,R-enantiomer of MMP-1-IN-1 (HY-152092). MMP-1-IN-1 (Compound 6) is a highly potent MMP-1 inhibitor with an IC50 of 0.034 μM.
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(Z)-16-(Ethylcarbamoylamino)hexadec-11-enoic acid
0 ImagesCat. No.: HY-139421CAS No.: 1184844-74-3(Z)-16-(Ethylcarbamoylamino)hexadec-11-enoic acid (Compound 21) is a vasorelaxant (EC50=5.7 μM) that can be used in cardiovascular disease research.
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Epibenzomalvin E
0 ImagesCat. No.: HY-176099Epibenzomalvin E is an isomer of Benzmalvin E. Benzomalvin E is an indoleamine 2,3-dioxygenase inhibitor.
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Methiopropamine 3’-thiophene isomer hydrochloride
0 ImagesCat. No.: HY-W202854CAS No.: 857361-90-1Methiopropamine 3’-thiophene isomer is an isomer of Methiopropamine that has the sulfur atom of the thiophene group at the 3 position.
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(S)-Sitagliptin phosphate (Standard)
0 ImagesCat. No.: HY-13749CRCAS No.: 823817-58-9Synonyms: (S)-MK-0431 phosphate (Standard)(S)-Sitagliptin phosphate (Standard) ((S)-MK-0431 phosphate (Standard)) is the analytical standard of (S)-Sitagliptin (phosphate) (HY-13749C). This product is intended for research and analytical applications. (S)-Sitagliptin phosphate ((S)-MK-0431 phosphate) is the S-isomer of Sitagliptin phosphate (HY-13749A). Sitagliptin phosphate (MK-0431 phosphate) is a potent DPP4 inhibitor. (S)-Sitagliptin phosphate can be used in diabetes research.
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(R)-2-Hydroxybutanoic acid sodium
0 ImagesCat. No.: HY-113381BCAS No.: 2307465-23-0Synonyms: (R)-α-Hydroxybutyric acid sodium(R)-2-Hydroxybutanoic acid ((R)-α-Hydroxybutyric acid) sodium is the R-isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite.
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(R)-L 888607 (Standard)
0 ImagesCat. No.: HY-111271BRCAS No.: 2446042-90-4(R)-L 888607 (Standard) is the analytical standard of (R)-L 888607 (HY-111271B). This product is intended for research and analytical applications. (R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite.
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(S)-NSC 121182
0 ImagesCat. No.: HY-180496CAS No.: 2197964-95-5(S)-NSC 121182 is an isomer of NSC 121182 (HY-180492). (S)-NSC 121182 does not cause statistically significant changes in CIRBP levels. (S)-NSC 121182 can be used in research on hypothermia.
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(±)-Levomepromazine (Standard)
0 ImagesSynonyms: (±)-Methotrimeprazine (Standard); dl-Methotrimeprazine (Standard)(±)-Levomepromazine ((±)-Methotrimeprazine) Standard is the analytical standard of (±)-Levomepromazine (HY-19489). This product is intended for research and analytical applications. (±)-Levomepromazine ((±)-Methotrimeprazine) is the racemate of Levomepromazine (HY-B1693).
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(Rac)-BW 245C
0 ImagesCat. No.: HY-101987ACAS No.: 75693-75-3
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(R)-BAY-747
0 ImagesCat. No.: HY-153369APurity: 98.63%Synonyms: (R)-BAY 1165747(R)-BAY-747 ((R)-BAY 1165747) is the (R)-enantiomer of BAY-747 (HY-153369). BAY-747 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC).
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5-Fluoro PB-22 6-hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172048CAS No.: 2365471-44-75-Fluoro PB-22 6-hydroxyisoquinoline isomer is a structural isomer of 5-Fluoro PB-22.
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(E/Z)-G256 dihydrochloride
0 ImagesCat. No.: HY-177148BCAS No.: 136623-15-9(E/Z)-G256 (dihydrochloride) is an isomer of G256 dihydrochloride (HY-177148A). G256 dihydrochloride is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 dihydrochloride undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 dihydrochloride generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 dihydrochloride produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 dihydrochloride can be used for research on arrhythmias.
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(R)-Mevalonic acid sodium
0 ImagesCat. No.: HY-W725424CAS No.: 96949-03-0Synonyms: (R)-MVA sodium(R) -Mevalonic acid ( (R) -MVA) sodium is an isomer of Mevalonic acid (HY-113071) . Mevalonic acid (MVA) is a precursor substance in the mevalonate pathway and is crucial for cell growth and proliferation.
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OPC-18750 hydrochloride
0 ImagesCat. No.: HY-167079ACAS No.: 145364-90-5OPC-18750 hydrochloride has positive inotropic and coronary vasodilatory effects.
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(+)-Talinolol
0 ImagesCat. No.: HY-108286BCAS No.: 71369-60-3Synonyms: (+)-Cordanum(+)-Talinolol is an isomer of Talinolol (HY-108286). Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity.
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(Z,E)-7,11-Hexadecadienal
0 ImagesCat. No.: HY-183957CAS No.: 96883-54-4(Z,E)-7,11-Hexadecadienal is a geometric isomer of Z7,Z11-16:Ald, the core component of the citrus leafminer sex pheromone. (Z,E)-7,11-Hexadecadienal acts as a sex pheromone tropism inhibitor; when mixed with the sex pheromone Z7,Z11-16:Ald, it blocks the tropism of male citrus leafminers towards the sex pheromone component. (Z,E)-7,11-Hexadecadienal can be used in insect resistance-related research.
