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mGluR7 Modulator

O-Phospho-L-serine

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Cat. No.: HY-15129

CAS No.: 407-41-0

Purity: 99.90%

Synonyms: L-Serine O-phosphate; L-SOP

O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
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VU0422288

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Cat. No.: HY-110190

CAS No.: 1630936-95-6

Purity: 99.94%

Synonyms: ML396

VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC₅₀s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.
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VU6012962

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Cat. No.: HY-114403

CAS No.: 2313526-86-0

Purity: 99.92%

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu₇ NAM) with an IC₅₀ of 347 nM.
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