Free Radical Scavengers
Free radical scavengers are bioactive substances that eliminate reactive free radicals. Free radicals with unpaired electrons easily damage lipids, proteins and DNA, causing oxidative stress and cell aging.
Free radical scavengers neutralize radicals by donating electrons or hydrogen atoms to form stable inert compounds. Their scavenging capacity is measured by in vitro assays including DPPH and ABTS tests.
Common natural scavengers are polyphenols, flavonoids, vitamin C and vitamin E. They are widely studied for food preservation, cosmetic anti-oxidation and treatments for oxidative damage-related diseases.
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Free Radical Scavengers Related Products (379)
Related Products (379)
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α-Glucosidase-IN-111
0 ImagesCat. No.: HY-181253CAS No.: 1004397-86-7α-Glucosidase-IN-111 (Compound 5d) is an α-Glucosidase inhibitor with a IC50 of 34.99 μg/mL. α-Glucosidase-IN-111 effectively scavenges DPPH free radicals and ABTS free radicals, with IC50 values of 5.33 and 5.84 μg/mL, respectively. α-Glucosidase-IN-111 can be used in the research of type 2 diabetes.
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N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N15536CAS No.: 1251952-80-3N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is a phenolic amide glycoside compound found in Suaeda japonica. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside exhibits antioxidant activity, capable of effectively scavenging DPPH free radicals and reducing the production of ROS induced by H2O2 in cells, thus protecting cells from oxidative stress damage. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is promising for research of cardiovascular diseases and neurodegenerative diseases.
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Myricadenin A
0 ImagesCat. No.: HY-N9229CAS No.: 1612239-23-2Myricadenin A is an iNOS inhibitor, capable of effectively inhibiting the production of NO (EC₅₀ = 18.1 μM). Myricadenin A has moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and relatively weak anti-tuberculosis activity (MIC = 80.0 μg/mL). Myricadenin A can be used in inflammation-related research.
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Anticancer agent 221
0 ImagesCat. No.: HY-163616CAS No.: 3038172-12-9Anticancer agent 221 (Compound 4h) is an orally active anticancer agent and an antioxidant agent. Anticancer agent 221 exhibits cytotoxicity to cancer cells A549 (IC50=22.09 µg/mL) and MCF-7 (IC50=6.40 µg/mL), and induces apoptosis. Anticancer agent 221 exhibits antioxidant efficacy with an IC50 of 42.46 μM in DPPH experiment. Anticancer agent 221 exhibits antitumor efficacy against breast cancer in mouse models.
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Phenazoviridin
0 ImagesCat. No.: HY-114651CAS No.: 155233-15-1Phenazoviridin is a free radical scavenger. Phenazoviridin shows strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibits antihypoxic activity in mice.
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Caspase-3/7 activator 4
0 ImagesCat. No.: HY-181163Caspase-3/7 activator 4 is a caspase-3 activator and caspase-7 activator. Caspase-3/7 activator 4 inhibits key enzymes in estrogen biosynthesis, including aromatase (IC50 = 38.3 nM) and steroid sulfatase (IC50 = 12.7 µM), and selectively suppresses COX-2 (IC50 = 5.38 µM). Caspase-3/7 activator 4 shows strong antioxidant activity (DPPH: IC50 = 16.26 µM). Caspase-3/7 activator 4 inhibits estrogen synthesis, suppresses estrogen availability, reduces prostaglandin production, increases caspase-3/7 expression, induces G0/G1 cell cycle arrest, induces apoptotic cell death, reduces circulating TNF-α and VEGFR-II levels, restores hepatorenal function markers and histoarchitecture, restores antioxidant defense enzyme activity, reduces lipid peroxidation, exerts antiproliferative activity against breast cancer cells, exerts antitumor activity in the Ehrlich ascites carcinoma models. Caspase-3/7 activator 4 can be used for the research of breast cancer, ehrlich ascites carcinoma.
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Pyracrenic acid
0 ImagesCat. No.: HY-130294CAS No.: 80832-44-6Pyracrenic acid is an elastase inhibitor (IC50 = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity.
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CV 3611
0 ImagesCat. No.: HY-106797CAS No.: 98829-12-0CV 3611 is a potent and orally active free radical scavenger. CV 3611 shows anti-inflammatory, antiarrhythmic and anticancer effects. CV 3611 can be used for the researches of cancer, inflammation and cardiovascular disease, such as hepatocellular carcinoma and acute pancreatitis.
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EMPO
0 ImagesEMPO is a free radical scavenger. EMPO is stable in phosphate buffers at physiological pH, its superoxide spin adducts are more durable and no hydroxyl adducts are produced when decaying. EMPO can be used in the study of free radicals.
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FASN/SCD-IN-1
0 ImagesCat. No.: HY-176274CAS No.: 3063509-61-2FASN/SCD-IN-1 is a Silybin (HY-N0779A) derivative, an orally active inhibitor of Fatty Acid Synthase (FASN)/Stearoyl-CoA Desaturase (SCD). FASN/SCD-IN-1 has shown in vitro activity in inhibiting lipid deposition, reducing FASN and SCD transcriptional levels, and exhibiting antioxidant, anti-inflammatory, and anti-fibrotic activities. FASN/SCD-IN-1 has demonstrated significant hepatoprotective effects in a rat model of acute liver injury. FASN/SCD-IN-1 ameliorates the pathological features of MASH liver, including steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative steatohepatitis (MASH). FASN/SCD-IN-1 can be used to study MASH.
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Auroglaucin
0 ImagesCat. No.: HY-N16406CAS No.: 41451-81-4Auroglaucin is a potent antioxidant. Auroglaucin shows 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity and superoxide radical scavenging activity with EC50 value of 74.6, 12.3 µM, respectively. Auroglaucin shows low activity for inhibiting the autoxidation of docosahexaenoic acid (DHA).
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Free radical scavenger 1
0 ImagesCat. No.: HY-155346CAS No.: 2989970-81-0Free radical scavenger 1 (compound 8) shows scavenging activity against the DPPH radical, with the IC50 of 43.39 μg/ml.
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Epicoccone B
0 ImagesCat. No.: HY-N10294CAS No.: 1067224-41-2Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC50 value of 10.8 μM, and has potent α-glucosidase inhibition with IC50 value of 27.3 μM. Anti-HIV activity.
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6-O-(E)-p-Hydroxy-cinnamoyl-glucose
0 ImagesCat. No.: HY-N21668CAS No.: 114297-65-36-O-(E)-p-Hydroxy-cinnamoyl-glucose is a phenylpropanoid glycoside isolated from Aristolochia manshuriensis Kom., acting as a free radical scavenger. 6-O-(E)-p-Hydroxy-cinnamoyl-glucose scavenges hydrated electrons, sulfate radical anions, and hydroxyl radicals by forming phenoxyl radicals at its conjugated carbonyl/keto group. 6-O-(E)-p-Hydroxy-cinnamoyl-glucose repairs oxidative DNA damage, DNA radical cations and anions, as well as deoxynucleotide radical cations (dAMP, dGMP, dCMP) and anions through electron transfer. 6-O-(E)-p-Hydroxy-cinnamoyl-glucose is useful for research on DNA damage-related diseases.
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AChE/BChE-IN-27
0 ImagesCat. No.: HY-174399AChE/BChE-IN-27 is a blood-brain barrier-permeable mixed inhibitor (Pe = 4.12) of AChE and BChE, with IC50 values of 3.72 μM and 9.65 μM, respectively. AChE/BChE-IN-27 has potent antioxidant activity with an IC50 value of 6.32 μM in the DPPH (HY-112053) assay and also exhibits potent in vitro antioxidant activity. AChE/BChE-IN-27 exhibits metal chelating properties. AChE/BChE-IN-27 has neuroprotective potential against oxidative stress. AChE/BChE-IN-27 significantly reduces intracellular reactive oxygen species (ROS). In in vivo experiments, AChE/BChE-IN-27 effectively restored AChE and BChE levels, improved cognition, and can be used for Alzheimer's disease (AD).
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Pedaliin 6''-acetate
0 ImagesCat. No.: HY-N10642CAS No.: 160789-41-3Pedaliin 6''-acetate (compound 10) is a natural product that can be isolated from Dracocephalum tanguticum. Pedaliin 6''-acetate shows antioxidative activity and cytoprotective effect on doxorubicin (DOX)-induced toxicity in H9c2 cardiomyocytes with an EC50 value of 19.1 μM.
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TrxR1-IN-1
0 ImagesCat. No.: HY-149390CAS No.: 3052303-04-2TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC50s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical.
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Isobellidifolin
0 ImagesIsobellidifolin, a xanthone, is a free radical scavenger and antioxidant compound. Isobellidifolin has potent antifungal effect.
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Lyoniside
0 ImagesCat. No.: HY-N3348CAS No.: 34425-25-7Lyoniside is a lignan glycoside with antioxidant, allelopathic and antifungal activities, which can be isolated from the rhizomes and stems of bilberry (Vaccinium myrtillus L.). Lyoniside exhibits radical scavenging properties with an IC50 value of 23 μg/mL in DPPH assay. Lyoniside inhibits the mycelial growth of Fusarium oxysporum and Mucor hiemalis at 50 μg/mL with inhibitory rates of 78% and 80%, respectively.
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Tyrosinase-IN-44
0 ImagesCat. No.: HY-178055CAS No.: 10200-72-3Tyrosinase-IN-44 (Compound 3) is a Tyrosinase inhibitor with IC50s of 0.47 and 0.53 μM for monophenolase and diphenolase, respectively. Tyrosinase-IN-44 has superior glutathione peroxidase-like catalytic and DPPH radical scavenging activity. Tyrosinase-IN-44 has potent antibrowning activity in banana and apple juices by directly inhibiting polyphenol oxidase (PPO) and offering antioxidant activity. Tyrosinase-IN-44 can be used for redox regulation and food preservation.
