PSMA Inhibitor

PSMA Inhibitors (26):

Cat. No.	Product Name	Effect	Purity

HY-W054292

tert-Butyl-DCL	Inhibitor	99.93%
Tert-Butyl-DCL is a PSMA inhibitor. Tert-Butyl-DCL Tert-Butyl-DCL can be used in the research of prostate cancer.

HY-P99517

Voxalatamab	Inhibitor	99.90%
Voxalatamab (JNJ-63898081) is a bispecific IgG4 antibody targeting PSMA and CD3. Voxalatamab attacks PSMA-expressing tumor cells by activating T cells. Voxalatamab has anticancer activity and is being studied for the treatment of solid tumors such as prostate cancer.

HY-P9992

Pelgifatamab	Inhibitor	99.884%
Peligifatamab is a PSMA-targeted α-radioimmunoconjugate with an EC₅₀ of 1.2 nM against human targets. Peligifatamab induces DNA damage, DNA double-strand breaks, cell cycle arrest and apoptosis (Apoptosis) in PSMA-positive prostate cancer cells. Peligifatamab reduces cell viability in a manner dependent on cellular PSMA expression levels. Peligifatamab inhibits tumor growth and tumor-induced abnormal bone growth in prostate cancer bone metastasis models. Peligifatamab exhibits antitumor efficacy in subcutaneous prostate cancer models and xenograft models. Peligifatamab can be used for the research of metastatic castration-resistant prostate cancer.

HY-139840

GCPII-IN-1	Inhibitor	99.83%
GCPII-IN-1 (Compound 2) is a GCPII (also known as PSMA) inhibitor with a K_i of 44.3 nM. GCPII-IN-1 can be used in the research of prostate cancer.

HY-P991204

Anti-PSMA Antibody	Inhibitor
Anti-PSMA Antibody (ARX517 antibody) is a humanized IgG1 monoclonal antibody that targets PSMA. Anti-PSMA Antibody is the antibody part of the ADC molecule ARX517. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991359

Anti-FOLH1/PSMA Antibody (J591)	Inhibitor
Anti-FOLH1/PSMA Antibody (J591) (MEDI3726 antibody) is a human monoclonal antibody (mAb) targeting FOLH1/PSMA. Anti-FOLH1/PSMA Antibody (J591) can be used in Prostate cancer research.

HY-139840A

GCPII-IN-1 TFA	Inhibitor	99.58%
GCPII-IN-1 (Compound 2) TFA is a GCPII (also known as PSMA) inhibitor with a K_i of 44.3 nM. GCPII-IN-1 TFA can be used in the research of prostate cancer.

HY-158266

DOTA-PSMA-EB-01	Inhibitor
DOTA-PSMA-EB-01 (Compound LNC1003) is a specific inhibitor of PSMA (IC₅₀= 10.77 nM).DOTA-PSMA-EB-01 enhances the uptake and retention time of ¹⁷⁷Lu in tumors. DOTA-PSMA-EB-01 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-163683

EB-PSMA-617	Inhibitor
EB-PSMA-617 is a modified form of PSMA-617 that has enhanced pharmacokinetic properties by conjugating it to Evans Blue (EB) to extend its circulation half-life to improve prostate tumor uptake and radiotherapy efficacy. In preclinical studies using PC3-PIP-loaded mice, EB-PSMA-617 demonstrated prolonged blood half-life, increased accumulation in PSMA-positive tumors, and successful tumor elimination with lower radioactivity.

HY-162779

CDD-3290	Inhibitor	98.99%
CDD-3290 (Compound 20) is a prostate-specific antigen (PSA) inhibitor with a K_i value of 216 nM. CDD-3290 also inhibits α-chymotrypsin and elastase.

HY-P991708

Olsutamig	Inhibitor
Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells.

HY-173476

TcO-ABX474	Inhibitor
TcO-ABX474 (TcO-5) is a potent prostate-specific membrane antigen (PSMA) inhibitor with a K_d value of 6.1 nM. TcO-ABX474 inhibits prostate cancer cell growth and metastasis. TcO-ABX474 is promising for research of prostate cancer.

HY-129615

MIP-1072	Inhibitor
MIP-1072 is a small molecule specific prostate-specific membrane antigen (PSMA) inhibitor. MIP-1072 inhibits the glutamate carboxypeptidase activity of PSMA with an K_i value of 4.6 nM. MIP-1072 is promising for research of prostate cancer.

HY-177808

A9g sodium	Inhibitor
A9g sodium is an RNA aptamer that inhibits the enzymatic activity of prostate-specific membrane antigen (PSMA).

HY-123733

MIP-1095	Inhibitor
MIP-1095 potently inhibits the glutamate carboxypeptidase activity of PSMA (K_i =0.24 nM).

HY-P991360

MLN 591	Inhibitor
MLN 591 is a human monoclonal antibody (mAb) targeting PSMA. MLN 591 can be used in Prostate cancer research.

HY-163196

PSMA-IN-4	Inhibitor
PSMA-IN-4 (compound 9) is a potent inhibitor of PSMA, with the IC₅₀ value of 1.2 μM.

HY-P992094

Capromab	Inhibitor
Capromab is an anti-human PSMA-targeting monoclonal antibody. Capromab binds specifically to the intracellular domain of PSMA, does not undergo internalization after binding, and targets necrotic cells with disrupted membranes. Capromab can be used for the research of prostate cancer.

HY-149297

PSMA-IN-1	Inhibitor
PSMA-IN-1 (compound 23) is an inhibitor of PSMA with a K_i value of 2.49 nM. PSMA-IN-1 inhibits tumor growth with high selectivity and specificity in PSMA+ xenograft models. PSMA-IN-1 is a NIR probe (λ_EX: 620 nm; λ_EM: 670 nm) used for tumor disappearance. PSMA-IN-1 can be used for research on prostate cancer.

HY-174808

SC691	Inhibitor
SC691 is a PSMA inhibitor. SC691 can be labeled with ⁶⁸Ga(III). SC691 can be used for imaging diagnosis of prostate cancer.

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