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Cat. No.: HY-136622

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A-420983

A-420983 is a potent, orally active inhibitor of Lck and can be used in studies involving animal models of delayed-type hypersensitivity and organ transplant rejection.

For research use only. We do not sell to patients.

CAS No.: 330789-03-2
Formula: C₃₃H₃₉N₉O₂
Molecular Weight:593.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

A-420983 Chemical Structure

CAS No.: 330789-03-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

A-420983 is a potent, orally active inhibitor of Lck and can be used in studies involving animal models of delayed-type hypersensitivity and organ transplant rejection^[1].

All Src Isoforms :

Chemical Information

CAS No. 330789-03-2
Molecular Weight 593.72
Formula C₃₃H₃₉N₉O₂
SMILES

O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Borhani DW, et al. A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. Bioorg Med Chem Lett. 2004;14(10):2613-2616. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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