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Amoscanate (Synonyms: CGP4540)

Cat. No.: HY-129051
Handling Instructions

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma.

For research use only. We do not sell to patients.

Amoscanate Chemical Structure

Amoscanate Chemical Structure

CAS No. : 100990-46-3

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Description

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].

In Vivo

Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1].
Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].
Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].
Amoscanate elicits massive ultrastructural damage in ependymal cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 500 mg/kg
Administration: P.o.; 10 days
Result: Destructed ependyma and periventricular brain.
Animal Model: Sprague-Dawley rats[1]
Dosage: 250 and 500 mg/kg
Administration: P.o.; 28 days
Result: Elicited necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.
Animal Model: Sprague-Dawley rats[1]
Dosage: 25~500 mg/kg
Administration: P.o.; 20 days
Result: Elicited progressive necrosis of ependymal.
Molecular Weight

271.29

Formula

C₁₃H₉N₃O₂S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Amoscanate
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