1. Anti-infection
  2. Parasite
  3. Antiparasitic agent-9

Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite.

For research use only. We do not sell to patients.

Antiparasitic agent-9 Chemical Structure

Antiparasitic agent-9 Chemical Structure

CAS No. : 2516237-50-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite[1].

IC50 & Target

Mite

 

In Vivo

Antiparasitic agent-9 (compound 47) (15 mg/kg, Orally, twice each day for 7 days) reduces adult worm burden in the jird L. sigmodontis infection model[1].
Antiparasitic agent-9 (2 mg/kg (IV), 10 and 30 mg/kg (PO); once) shows a brain to plasma ratio of 0.08, suggesting limited brain exposure[1].
Pharmacokinetic Parameters of Antiparasitic agent-9 in male Male CD-1 mouse[1].

PO (30 mg/kg) PO (10 mg/kg) IV (2 mg/kg)
Cmax (μM) 13.9 5.27 ± 0.83
Tmax (h) 0.50 4.0 ± 2.8
AUC0-inf (μM·h) 121 68.1±NC
CL (mL/min/kg) 3.6 ± 0.22
Vd ss (mL/kg) 0.74 ± 0.08
F (%) 57
brain/plasma [b]/[p] 0.08
efflux ratio (ER) 12

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (infected withL. sigmodontis, 6-8 weeks)[1]
Dosage: 15 mg/kg
Administration: Orally, twice each day for 7 days
Result: Showed a significant worm burden reduction of 59% at 15 mg/kg.
Animal Model: Male CD-1 mouse (n = 4)[1]
Dosage: 2 mg/kg (IV), 10 and 30 mg/kg (PO)
Administration: IV, PO, once (Pharmacokinetic Analysis)
Result: Showed a brain to plasma ratio of 0.08, suggesting limited brain exposure.
Molecular Weight

384.46

Formula

C18H20N6O2S

CAS No.
SMILES

CC(N(C1=CC=CN=C1NC2=NC(C3=NC=C(OC(C)C)C=C3)=NS2)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antiparasitic agent-9 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antiparasitic agent-9
Cat. No.:
HY-151133
Quantity:
MCE Japan Authorized Agent: