Antiparasitic agent-9
Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite.
For research use only. We do not sell to patients.
- CAS No.: 2516237-50-4
- Formula: C18H20N6O2S
- Molecular Weight:384.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Mite |
Antiparasitic agent-9 (2 mg/kg (IV), 10 and 30 mg/kg (PO); once) shows a brain to plasma ratio of 0.08, suggesting limited brain exposure[1].
Pharmacokinetic Parameters of Antiparasitic agent-9 in male Male CD-1 mouse[1].
| PO (30 mg/kg) | PO (10 mg/kg) | IV (2 mg/kg) | |
| Cmax (μM) | 13.9 | 5.27 ± 0.83 | |
| Tmax (h) | 0.50 | 4.0 ± 2.8 | |
| AUC0-inf (μM·h) | 121 | 68.1±NC | |
| CL (mL/min/kg) | 3.6 ± 0.22 | ||
| Vd ss (mL/kg) | 0.74 ± 0.08 | ||
| F (%) | 57 | ||
| brain/plasma [b]/[p] | 0.08 | ||
| efflux ratio (ER) | 12 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (infected withL. sigmodontis, 6-8 weeks)[1]
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Dosage:15 mg/kg
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Administration:Orally, twice each day for 7 days
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Result:Showed a significant worm burden reduction of 59% at 15 mg/kg.
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Animal Model:Male CD-1 mouse (n = 4)[1]
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Dosage:2 mg/kg (IV), 10 and 30 mg/kg (PO)
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Administration:IV, PO, once (Pharmacokinetic Analysis)
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Result:Showed a brain to plasma ratio of 0.08, suggesting limited brain exposure.
Chemical Information
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CAS No. 2516237-50-4
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Molecular Weight 384.46
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Formula C18H20N6O2S
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SMILES
CC(N(C1=CC=CN=C1NC2=NC(C3=NC=C(OC(C)C)C=C3)=NS2)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiparasitic agent-9 Related Classifications
HY-151133 Related Classifications
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