Birinapant

(Synonyms: TL32711)
44 Cited Publications
Kundenbewertung

Based on 44 publication(s) in Google Scholar

Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 99.70%
  • CAS. Nr.: 1260251-31-7
  • Formel: C42H56F2N8O6
  • Molecular Weight:806.94
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Biologische Aktivität
  • Chemical Information
  • Lösungsmittel & Löslichkeit
  • Reinheit & Dokumentation
  • Verweise
  • Help & FAQs

Publications Citing Use of MedChemExpress (MCE) Birinapant

More
Customer Validation & Images
Cell Proliferation/Viability AssayIn Vivo Efficacy StudyFlow CytometryWB
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Flow Cytometry
  • WB
  • WB
  • WB

Alle IAP Isoform-spezifische Produkte anzeigen

More

Alle HIV Isoform-spezifische Produkte anzeigen

More
100 mg

Angebot einholen Auf Lager

Please select quantity
Amount: USD 0.00