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Colivelin

97 Cited Publications
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Based on 97 publication(s) in Google Scholar

Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

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  • Reinheit: 99.92%
  • CAS. Nr.: 867021-83-8
  • Formel: C119H206N32O35
  • Molecular Weight:2645.10
  • Speicherung:

    Sealed storage, away from moisture.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Colivelin Chemical Structure
    Colivelin Chemical Structure
  • Experimental Validation Results for Colivelin
  • Experimental Validation Results for Colivelin
  • Experimental Validation Results for Colivelin
  • Experimental Validation Results for Colivelin
  • Experimental Validation Results for Colivelin
  • Experimental Validation Results for Colivelin
CAS. Nr.: 867021-83-8
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  • Colivelin Chemical Structure
    Colivelin Chemical Structure
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    Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 29;23(1):258. [Abstract]

    Customer Validation
     (A) Schematic diagram of the synthesis steps of PN@Col nanoparticles(61 mg (-)-Epigallocatechin Gallate (EGCG), 10 mg Glycine and 2 mg Colivelin);(B) Morphological features of PN (top) and PN@Col (bottom) observed using TEM (scale bar: 100 nm/200 nm);(C) Morphology of PN (top) and PN@Col (bottom) observed using SEM (scale bar: 5 μm/1 μm);

  • 1/16

    Colivelin purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Oct 2;23(1):1043. [Abstract]

    Customer Validation
     Mice in the sti-STAT3 group were given Colivelin (1 mg/kg) via intraperitoneal injection daily. The left panel showed that VISTA overexpression and Colivelin injection (sti-STAT3, 1 mg/kg/day) affected tumor growth in C57BL/6 J mice. The right panel showed tumor volumes measured by growth curve every three days from day 7 to day 16 after cell transplantation.

  • 1/16

    Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]

    Customer Validation
     Western blot analysis showed the expression levels of p-STAT3, CPT1A, and CPT1B in MDSCs after treatment with Colivelin (50 µg/mL; 4 h).

  • 1/16

    Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]

    Customer Validation
     ELISA measured the ability of Colivelin (50 µg/mL; 4 h) treatment to inhibit T cell proliferation and release IFNγ and GzmB.

  • 1/16

    Colivelin purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jul 11;22(1):409. [Abstract]

    Customer Validation
     T cell proliferation assay measured the ability of Colivelin (50 µg/mL; 4 h) treatment to inhibit T cell proliferation and release IFNγ and GzmB.

  • 1/16

    Colivelin purchased from MedChemExpress. Usage Cited in: Aging. 2020 May 15;12(10):9066-9084. [Abstract]

    Customer Validation
     The protein expression of the biomarkers of JAK-STAT signaling pathway. The expression of TNF-α, IFN-β, IL-6 and MCP-1 is all upregulated and IL-4 expression are downregulated in the group treated with miR-142-5p versus the NC group, and it could be rescued by Colivelin.

  • Colivelin