A2AR modulator-1
A2AR modulator-1 (Compound 45) is a selective negative allosteric adenosine A2a receptor (A2aR) modulator with an IC50 value of 9 nM. A2AR modulator-1 reduces the affinity of endogenous adenosine for the receptor and inhibits cAMP signaling pathway activation. A2AR modulator-1 potently restores pCREB phosphorylation in CD4+ T cells, reversing immunosuppression in the tumor microenvironment, and shows potential to suppress tumor growth and metastasis in triple-negative breast cancer models.
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- CAS. Nr.: 3007566-23-3
- Formel: C23H20N6
- Molecular Weight:380.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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A2AR 9 nM (IC50) |
Chemical Information
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CAS. Nr. 3007566-23-3
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Molecular Weight 380.45
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Formel C23H20N6
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SMILES
N#CC1=C(C2=CC=CC(C3=CC=CN=C3)=C2)C(C#N)=C(N4CCCCC4)N=C1N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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