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Art. -Nr.: HY-145704

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Antimalarial agent 8

Antimalarial agent 8 (Compound 7e) is a novel orally active class of antimalarials. Antimalarial agent 8 is potent in vitro against P. falciparum and is orally efficacious (40 mg/kg) in an in vivo mouse model of malaria.

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CAS. Nr.: 2715222-97-0
Formel: C₂₂H₂₁Cl₃N₄O
Molecular Weight:463.79

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antimalarial agent 8 Chemical Structure

CAS. Nr.: 2715222-97-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Plasmodium

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Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	CC₅₀	32 μM Compound: 7e.HCl	Cytotoxicity against human HEK293 cells by resazurin based cell viability assay Cytotoxicity against human HEK293 cells by resazurin based cell viability assay	[PMID: 35300096]
Hepatocyte	CC₅₀	8500 nM Compound: 7e.HCl	Cytotoxicity against human hepatocytes measured after 96 hrs by DAPI staining based fluroscence assay Cytotoxicity against human hepatocytes measured after 96 hrs by DAPI staining based fluroscence assay	[PMID: 35300096]

Chemical Information

CAS. Nr. 2715222-97-0
Molecular Weight 463.79
Formel C₂₂H₂₁Cl₃N₄O
SMILES

O=C(C1=CC2=C(NC3=C2C=CC=C3C)C(C4=CC(Cl)=C(Cl)C=C4)=N1)NCCNC.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mathew J, et al. Malaria Box-Inspired Discovery of N-Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials. ACS Med Chem Lett. 2022;13(3):365-370. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Antimalarial agent 8

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Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Antimalarial agent 8 Related Classifications

HY-145704 Related Classifications