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Art. -Nr.: HY-P990033

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Biologically Validated

Anzurstobart

(Synonyms: CC-95251; BMS-986351)

Kundenbewertung

Based on 1 Customer Validation

Anzurstobart (CC-95251; BMS-986351) is a CD47/SIRPα inhibitor with human SIRPα K_d of 0.0541 nM and human SIRPα IC₅₀ of 100 nM. Anzurstobart binds SIRPα at a CD47-overlapping site, blocks CD47-SIRPα interactions, inhibits CD47-SIRPα axis signaling, and binds across 6 prevalent human SIRPα haplotypes. Anzurstobart binds SIRPγ and inhibits CD47-SIRPγ interactions. Anzurstobart can be used for the research of non-Hodgkin's lymphoma, colorectal cancer, squamous cell carcinoma of the head and neck, diffuse large B-cell lymphoma, and advanced solid and hematologic malignancies.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.0%
CAS. Nr.: 2543693-10-1
Molecular Weight:144.66 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anzurstobart Chemical Structure

CAS. Nr.: 2543693-10-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

SIRPa/CD172a

In Vitro

Anzurstobart (CC-95251) potently blocks CD47-SIRPα binding in a dose-dependent manner, with near-complete inhibition at 100 nM^[1].
Anzurstobart (50 nM; 180 seconds) demonstrates strong binding coverage across the six most prevalent human SIRPα haplotypes^[1].
Anzurstobart (20 nmol/L; 10 minutes preincubation, 3-hour coculture) alone dose-dependently increases macrophage-mediated phagocytosis of GP2d, GP5d, and SW480 colorectal cancer cells^[1].
Anzurstobart (20 nmol/L; 10 minutes preincubation, 3-hour coculture) in combination with Rituximab (HY-P9913) dose-dependently enhances macrophage-mediated phagocytosis of OCI-Ly3, RIVA, Pfeiffer, and Karpas 422 DLBCL cells, while Anzurstobart alone has limited phagocytic activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	T_1/2	CL	V_dss
Cynomolgus Monkey^[2]	10 mg/kg	i.v.	1.50 h	183 μg/mL	227 h	186.48 mL/h/kg	99.80 mL/kg
Cynomolgus Monkey^[2]	30 mg/kg	i.v.	0.25 h	632 μg/mL	185 h	206.16 mL/h/kg	80.47 mL/kg
Cynomolgus Monkey^[2]	100 mg/kg	i.v.	1.50 h	1,984 μg/mL	217 h	200.88 mL/h/kg	91.93 mL/kg

In Vivo

Anzurstobart (CC-95251) (10-100 mg/kg; i.v.; single dose, repeat dose) results in dose-dependent peak serum concentrations, a half-life of 163-227 hours, and no hematologic cell depletion over 28 days in Macaca fascicularis^[1].
Anzurstobart (10-100 mg/kg; i.v.) is well-tolerated in healthy cynomolgus monkeys with no hematologic depletion observed^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys^[2]
Dosage:

10 mg/kg; 30 mg/kg; 100 mg/kg
Administration:

i.v.; single dose (day 1); repeat dose (day 15)
Result:

Reached peak serum concentrations (Cmax) of 183 μg/mL (10 mg/kg), 632 μg/mL (30 mg/kg), and 1984 μg/mL (100 mg/kg) after day 1 dose.
Reached peak serum concentrations (Cmax) of 183 μg/mL (10 mg/kg), 664 μg/mL (30 mg/kg), and 2276 μg/mL (100 mg/kg) after day 15 dose.
Exhibited half-life (T1/2) ranging from 163 to 227 hours across individual animals.
Showed clearance rates ranging from 7.77 to 15.48 mL/day/kg.
Caused no depletion of white blood cells, monocytes, lymphocytes, or red blood cells over 28 days of exposure.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

140885 [NCBI]

Accession

P78324

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Flow Cytometry analysis of U937 cells labelling SIRPa/CD172a (red) with Anzurstobart (anti-SIRPa/CD172a) (HY-P990033). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

Chemical Information

CAS. Nr. 2543693-10-1
Appearance Liquid
Molecular Weight 144.66 kDa
Color Colorless to light yellow
SMILES

[Anzurstobart]
Synonyms

CC-95251; BMS-986351
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Chan H, et al. Discovery and Preclinical Activity of BMS-986351, an Antibody to SIRPα That Enhances Macrophage-mediated Tumor Phagocytosis When Combined with Opsonizing Antibodies. Cancer Res Commun. 2024;4(2):505-515. [Content Brief]

[2]. Chan H, et al. Discovery and Preclinical Characterization of CC-95251, an Anti-SIRPα Antibody That Enhances Macrophage-Mediated Phagocytosis of Non-Hodgkin Lymphoma (NHL) Cells When Combined with Rituximab. Blood. 2021;2271-2272.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
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MCE Japan Authorized Agent:

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Anzurstobart

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Antibody Inhibitor Library

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anzurstobart Related Classifications

HY-P990033 Related Classifications