BAY-0069
Based on 1 Customer Validation
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.07%
- CAS. Nr.: 420826-65-9
- Formel: C22H16BrN3O4
- Molecular Weight:466.28
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
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hPPARγ 6.3 nM (IC50) |
mouse PPARγ 24 nM (IC50) |
BAY-0069 inhibits CYP2C8 with an IC50 of 4.3 μM[1].
BAY-0069 (0.1 nM-1 μM; 7 days) leads to antiproliferative effects in the PPARγ-amplified cell line UM-UC-9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PPARγ-amplified cell line UM-UC-9
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Concentration:0.0001, 0.001, 0.01, 0.01 and 1 μM
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Incubation Time:7 days
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Result:Inhibited PPARγ-amplified cell line UM-UC-9 with an IC50 of 2.54 nM.
Pharmacokinetic Parameters of BAY-0069 in female NMRI nu/nu mice[1].
| Route | P.O. (100 mg/kg) | I.P. | S.C. |
| AUC0-tlast (mg/L·h) | 0.074 | 0.26 | 0.045 |
| Cmax (nM) | 35 | 59 | 4.4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 420826-65-9
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Appearance Solid
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Molecular Weight 466.28
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Formel C22H16BrN3O4
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=C(OC(C2=CC=C(CC)C=C2)=N3)C3=C1)C4=CC([N+]([O-])=O)=CC=C4Br
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (214.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1446 mL | 10.7232 mL | 21.4463 mL | 53.6159 mL |
| 5 mM | 0.4289 mL | 2.1446 mL | 4.2893 mL | 10.7232 mL | |
| 10 mM | 0.2145 mL | 1.0723 mL | 2.1446 mL | 5.3616 mL | |
| 15 mM | 0.1430 mL | 0.7149 mL | 1.4298 mL | 3.5744 mL | |
| 20 mM | 0.1072 mL | 0.5362 mL | 1.0723 mL | 2.6808 mL | |
| 25 mM | 0.0858 mL | 0.4289 mL | 0.8579 mL | 2.1446 mL | |
| 30 mM | 0.0715 mL | 0.3574 mL | 0.7149 mL | 1.7872 mL | |
| 40 mM | 0.0536 mL | 0.2681 mL | 0.5362 mL | 1.3404 mL | |
| 50 mM | 0.0429 mL | 0.2145 mL | 0.4289 mL | 1.0723 mL | |
| 60 mM | 0.0357 mL | 0.1787 mL | 0.3574 mL | 0.8936 mL | |
| 80 mM | 0.0268 mL | 0.1340 mL | 0.2681 mL | 0.6702 mL | |
| 100 mM | 0.0214 mL | 0.1072 mL | 0.2145 mL | 0.5362 mL |
BAY-0069 Related Classifications
HY-148351 Related Classifications
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