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Art. -Nr.: HY-183139

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CD666

CD666 is a selective retinoic acid receptor-γ (RAR-γ) agonist with a K_d of 68 nM. CD666 inhibits proliferation of cancer cells and shows synergistical effects and anti-AP-1 activity with IFN-γ. CD666 can be used for the research of breast cancer.

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CAS. Nr.: 144006-45-1
Formel: C₂₄H₂₈O₃
Molecular Weight:364.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CD666 Chemical Structure

CAS. Nr.: 144006-45-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

RAR-γ

68 nM (Kd)

Alle RAR/RXR Isoform-spezifische Produkte anzeigen :

Alle AP-1 Isoform-spezifische Produkte anzeigen :

In Vitro

CD666 binds selectively to recombinant RAR-γ with a K_d of 68 nM, showing ~33-fold and ~34-fold lower affinity for RAR-α (K_d = 2240 nM) and RAR-β (K_d = 2300 nM), respectively^[1].
CD666 (0.1-1000 μM) potently inhibits proliferation of RA-sensitive MCF-7, ZR-75-1, T47D, and SKBR-3 human breast cancer cell lines, but does not inhibit proliferation of Retinoic acid (HY-14649 )-resistant 734-B and BT-20 cell lines when used alone^[1].
CD666 acts synergistically with IFN-γ to inhibit proliferation of MCF-7, SKBR-3, BT-20, ZR-75-1, T47D, and 734-B human breast cancer cell lines, with combination
index values < 1 across all tested inhibitory concentrations^[1].
CD666 (1 μM; 24 h) alone does not suppress TPA-mediated AP-1 activity in MCF-7 human breast cancer cells, but in combination with IFN-γ, it significantly reduces AP-1 promoter activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 144006-45-1
Molecular Weight 364.48
Formel C₂₄H₂₈O₃
SMILES

CC1(C2=CC(C(O)/C=C/C3=CC=C(C=C3)C(O)=O)=CC=C2C(C)(CC1)C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Widschwendter M, et al. Activity of retinoic acid receptor-gamma selectively binding retinoids alone and in combination with interferon-gamma in breast cancer cell lines. Int J Cancer. 1997;71(3):497-504. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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CD666

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