CliMB-325
CliMB-325 is an HSP90 inhibitor that can induce MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells. CliMB-325 enhances T cell activation and exhibits lower toxicity. CliMB-325 can be used for the study of colorectal cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C15H9Cl2N9
- Molecular Weight:386.20
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
HSP90 |
MHC I 498 nM (EC50) |
CliMB-325 induces MHC-I (EC50 = 498 nM) expression on the surface of CT26 murine colorectal cancer cells[1].
CliMB-325 exhibits low cytotoxicity against CT26 murine colorectal cancer cells with a CC50 of 1.3 μM[1].
CliMB-325 (1 μM, 48 h) increases T cell activation (measured by β-galactosidase activity) by 1.6-fold when MC38-OVA cells, after a 48-hour incubation, are co-cultured with B3Z T cells[1].
CliMB-325 adds 290 unique MHC-I peptides, five times more than the untreated group, and 81.3% of the peptides are unique to the CliMB-325 group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 386.20
-
Formel C15H9Cl2N9
-
SMILES
ClC1=C2N=CN(C2=NC(N)=N1)CC3=CN(N=N3)C4=CC=C(C=C4C#N)Cl
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CliMB-325 Related Classifications
HY-179211 Related Classifications
Powered by Bioz