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Art. -Nr.: HY-151188

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DHU-Se1

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1.

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Formel: C₂₃H₂₃N₃OSSe
Molecular Weight:468.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

DHU-Se1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Selenium, iNOS, TNF-α^[1]

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells^[1].
DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors^[1].
DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

RAW cells
Concentration:

50 μM
Incubation Time:

24 h
Result:

Displayed low biological toxicity with a survival rate larger than 80%.

RT-PCR^[1]

Cell Line:

RAW cells (co-treated with 100 ng/mL LPS)
Concentration:

20 μM
Incubation Time:

24 h
Result:

Reduced the expression of TNF-α and iNOS significantly.

Western Blot Analysis^[1]

Cell Line:

RAW 264.7 macrophages (co-treated with 100 ng/mL LPS)
Concentration:

20 μM
Incubation Time:

24 h
Result:

Significantly decreased the expression level of iNOS, indicating that M0 to M1 polarization was blocked.
Released the reactive selenium compound.

Chemical Information

Molecular Weight 468.47
Formel C₂₃H₂₃N₃OSSe
SMILES

CN(C1=CC=C2C(SC3=C(N2C([Se]C4=CC=CC=C4)=O)C=CC(N(C)C)=C3)=C1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Peng H, et al. HOCl-Activated Reactive Organic Selenium Delivery Platform for Alleviation of Inflammation. Bioconjug Chem. 2022 Aug 26. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

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DHU-Se1

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen