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Art. -Nr.: HY-W750903

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Dihydroxanthohumol

Dihydroxanthohumol is a chalcone found in Humulus lupulus L. Dihydroxanthohumol is a nitric oxide (NO) production inhibitor. Dihydroxanthohumol slightly suppresses LPS (HY-D1056)/IFN-γ-induced iNOS protein expression and NO production. Dihydroxanthohumol exhibits cytotoxicity at high concentrations.

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CAS. Nr.: 102448-00-0
Formel: C₂₁H₂₄O₅
Molecular Weight:356.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Dihydroxanthohumol Chemical Structure

CAS. Nr.: 102448-00-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	74.41 μM Compound: 4, alpha,beta-Dihydroxanthohumol	Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 23434138]
MCF7	IC₅₀	9.15 μM Compound: 4, alpha,beta-Dihydroxanthohumol	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 23434138]
PC-3	IC₅₀	14.73 μM Compound: 4, alpha,beta-Dihydroxanthohumol	Cytotoxicity against human PC3 cells after 72 hrs by SRB assay Cytotoxicity against human PC3 cells after 72 hrs by SRB assay	[PMID: 23434138]
RAW264.7	IC₅₀	23 μM Compound: 3	Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs	[PMID: 15679315]

In Vitro

Dihydroxanthohumol (Compound 5) (1-100 μg/mL; 16 h) inhibits LPS (HY-D1056)/IFN-γ-induced NO production in mouse macrophage RAW 264.7 cells, and slightly suppresses iNOS protein expression at 5 μg/mL^[1].
Dihydroxanthohumol (10-100 μg/mL; 16 h) shows cytotoxicity to RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW 264.7 cells
Concentration:

1, 5, 10, 50, 100 μg/mL
Incubation Time:

16 h
Result:

Showed cell viability <50% at 50, 100 μg/mL.
Showed cell viability <80% at 10 μg/mL.
Showed cell viability >95% at 50, 100 μg/mL.

Chemical Information

CAS. Nr. 102448-00-0
Molecular Weight 356.41
Formel C₂₁H₂₄O₅
SMILES

O=C(CCC1=CC=C(C=C1)O)C2=C(C(C/C=C(C)\C)=C(C=C2OC)O)O
Structure Classification
- Flavonoids
- Dihydrochalcones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao F, et al. Inhibitors of nitric oxide production from hops (Humulus lupulus L.). Biol Pharm Bull. 2003;26(1):61-65. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Dihydroxanthohumol

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Dihydroxanthohumol Related Classifications

HY-W750903 Related Classifications