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Art. -Nr.: HY-106095

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DQ 2556

DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 102253-70-3
Formel: C₂₂H₁₉N₇O₆S₂
Molecular Weight:541.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

DQ 2556 Chemical Structure

CAS. Nr.: 102253-70-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]^[2]

β-lactam

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

DQ-2556 is active against Gram-positive bacteria, sensitive to methicillin-resistant Staphylococcus (MIC90 = 1.56-3.13 μg/mL), highly active against Streptococcus (MIC90 ≤ 0.05 μg/mL), and has limited activity against Enterococcus (MIC90 = 50 μg/mL)^[1]^[2].
DQ-2556 is active against Gram-negative bacteria, has an MIC₉₀ value of no more than 0.05 μg/mL against Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, etc. and sensitive to Haemophilus influenzae and Neisseria gonorrhoeae with MIC90 of 0.1 μg/mL^[1]^[2].
DQ-2556 has the same or ≤ 4-fold MIC₉₀ value against Staphylococcus aureus, Escherichia coli, and Proteus mirabilis^[1]^[2].
DQ-2556 (0.0008-12.5 μg, 4 h) induces the formation of filamentous and spherical structures in Escherichia coli, and also induced cell lysis at higher concentrations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DQ-2556 (0.2 mL/mice, s.c., single dose) exhibits ED₅₀s against infections with S. aureus, S. pneumoniae, E. coli, K pneumoniae, and S. marcescens of 0.37, 2.75, 0.0091, 0.23, and 0.029 mg/kg mg/kg of body weight, respectively in mice infection model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 102253-70-3
Molecular Weight 541.56
Formel C₂₂H₁₉N₇O₆S₂
SMILES

[O-]C(C1=C(C[N+]2=CC=C(C3=CN=CO3)C=C2)CS[C@@]([C@@H]4NC(/C(C5=CSC(N)=N5)=N\OC)=O)([H])N1C4=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fujimoto T, et al. In vitro activity of DQ-2556, a new cephalosporin. Antimicrob Agents Chemother. 1986 Oct;30(4):611-3. [Content Brief]

[2]. Ishida Y, et al. In vitro and in vivo activity of DQ-2556, a new cephalosporin. Chemotherapy. 1995 Jan-Feb;41(1):5-13. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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