FGA146
FGA146 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 2.19 μM, 0.96 μM and 0.87 μM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA146 reveals an antiviral activity against SARS-CoV-2.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C24H31N5O6
- Molecular Weight:485.53
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Alle Cathepsin Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
|
cathepsin L 0.87 μM (Ki) |
pET21-Mpro 0.96 μM (Ki) |
Mal-Mpro 2.19 μM (Ki) |
FGA146 reveals antiviral activity against SARS-CoV-2 with EC50 of 0.9 μM with low cytotoxicity[1].
FGA146 (25-100 μM) binds covalently to Mpro and decreases its thermal stability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Huh-7-ACE2
-
Concentration:0-100 μM
-
Incubation Time:24 h
-
Result:Exhibited a CC50 of over 100 μM.
Chemical Information
-
Molecular Weight 485.53
-
Formel C24H31N5O6
-
SMILES
O=C(N[C@@H](C[C@@H]1CCNC1=O)/C=C/[N+]([O-])=O)[C@H](CC(C)C)NC(C2=CC(C(OC)=CC=C3)=C3N2)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FGA146 Related Classifications
HY-161245 Related Classifications
Powered by Bioz