Art. -Nr.: HY-N6953

Garcinone D

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC₅₀ for CDK2/CyclinE1 is 28.23 μM). Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer.

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Reinheit: 99.30%
CAS. Nr.: 107390-08-9
Formel: C₂₄H₂₈O₇
Molecular Weight:428.47

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Garcinone D Chemical Structure

CAS. Nr.: 107390-08-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

p-STAT3

Alle STAT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa S3	IC₅₀	>10 μM Compound: 13	Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HepG2	IC₅₀	>10 μM Compound: 13	Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
HT-29	ED₅₀	2.3 μM Compound: 7	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 19839614]
HT-29	IC₅₀	>10 μM Compound: 13	Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
KB	IC₅₀	>10 μM Compound: 13	Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay	[PMID: 30978023]
MCF7	IC₅₀	>10 μM Compound: 13	Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 30978023]

In Vitro

Garcinone D (5-400 μM; 24 h) regulates the cell viability of C17.2 neural stem cells. And increases cell viability at 5-10 μM, while significantly reduces cell viability at 20-40 μM^[1].
Garcinone D (5 μM; 24 h) promotes the transition of C17.2 neural stem cells in the G1-S phase and arrests the cell cycle in the S phase^[1].
Garcinone D (3-10 μM; 6-24 h) increases the levels of p-STAT3, Cyclin D1, Nrf2 and HO-1 proteins in C17.2 neural stem cells in a concentration- and time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C17.2 neural stem cells
Concentration:

5 μM, 10 μM, 20 μM, 40 μM
Incubation Time:

24 h
Result:

Significantly increased cell viability at 5 and 10 μM; and significantly decreased cell viability at at 20 and 40 μM.
The percentage of BrdU-positive cells was 1.4-fold higher in the 5 μM group compared with the control, indicating enhanced cell proliferation.
The proportion of cells in the S phase increased from 39.12% to 54.55% after treatment with 5 μM, suggesting promotion of G1-S transition.

Western Blot Analysis^[1]

Cell Line:

C17.2 neural stem cells
Concentration:

3 μM, 5 μM, 10 μM
Incubation Time:

3 h, 6 h, 12 h, 24 h
Result:

Increased the protein levels of p-STAT3, Cyclin D1, Nrf2, and HO-1 in a dose- and time-dependent manner.

Chemical Information

CAS. Nr. 107390-08-9
Appearance Solid
Molecular Weight 428.47
Formel C₂₄H₂₈O₇
Color Light yellow to yellow
SMILES

CC(C)(O)CCC1=C(OC)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

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Journal Impact Factor

Phytomedicine

Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway. [Abstract]

2022 Oct:105:154385. PMID: 35987015
Environ Health

2025 Dec 21.
J Immunol

HMGB1 inhibits the IFN-γ-induced PD-L1 expression in NSCLC. [Abstract]

2025 Jun 28:vkaf125. PMID: 40580518
Food Anal Methods

2023 May 9.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (116.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3339 mL

11.6694 mL

23.3389 mL

5 mM

0.4668 mL

2.3339 mL

4.6678 mL

10 mM

0.2334 mL

1.1669 mL

2.3339 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12. [Content Brief]

[2]. Nauman MC, et al. Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (Garcinia mangostana): a structure-activity relationship study. Nat Prod Res. 2021 Dec;35(23):5429-5433. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3339 mL	11.6694 mL	23.3389 mL	58.3471 mL
	5 mM	0.4668 mL	2.3339 mL	4.6678 mL	11.6694 mL
	10 mM	0.2334 mL	1.1669 mL	2.3339 mL	5.8347 mL
	15 mM	0.1556 mL	0.7780 mL	1.5559 mL	3.8898 mL
	20 mM	0.1167 mL	0.5835 mL	1.1669 mL	2.9174 mL
	25 mM	0.0934 mL	0.4668 mL	0.9336 mL	2.3339 mL
	30 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9449 mL
	40 mM	0.0583 mL	0.2917 mL	0.5835 mL	1.4587 mL
	50 mM	0.0467 mL	0.2334 mL	0.4668 mL	1.1669 mL
	60 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9725 mL
	80 mM	0.0292 mL	0.1459 mL	0.2917 mL	0.7293 mL
	100 mM	0.0233 mL	0.1167 mL	0.2334 mL	0.5835 mL

Keywords

Garcinone D

4 Cited Publications

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Garcinone D

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Publications Citing Use of MedChemExpress (MCE) Garcinone D

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Garcinone D Related Classifications

HY-N6953 Related Classifications