CAP1 - cyclase associated actin cytoskeleton regulatory protein 1 Gene

Also Known as CAP; CAP1-PEN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10487

About CAP1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,040,240-40,072,648 (from NCBI)

This gene has 19 transcripts (splice variants), 230 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 105.5), lymph node (RPKM 89.3) and 25 other tissues.

Summary

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with Other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]

CAP1 Products (14)

mRNA Protein Name
NM_001105530.2 NP_001099000.2 adenylyl cyclase-associated protein 1 isoform a
NM_001330502.2 NP_001317431.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350475.2 NP_001337404.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350476.2 NP_001337405.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350477.3 NP_001337406.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350478.2 NP_001337407.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350479.2 NP_001337408.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350480.2 NP_001337409.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350481.2 NP_001337410.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350482.2 NP_001337411.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350483.2 NP_001337412.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350484.2 NP_001337413.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350485.2 NP_001337414.2 adenylyl cyclase-associated protein 1 isoform b
NM_006367.4 NP_006358.2 adenylyl cyclase-associated protein 1 isoform a

CAP1 Protein Structure

CAP_N

CAP_N: Adenylate cyclase associated (CAP) N terminal (4 - 305)

CAP_C

CAP_C: Adenylate cyclase associated (CAP) C terminal (317 - 473)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

adenylyl cyclase-associated protein 1

  • CAP, adenylate cyclase-associated protein 1

CAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
CAP1 Q01518 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Confocal
19273555
Cross
CAP1 Q01518 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Anti Tag CoIP
19273555
Cross
CAP1 Q01518 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Y2H Pooling
19273555
Intra
CAP1 Q01518 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anteroseptal Myocardial Infarction
Luminal Breast Carcinoma A

  • Breast Tumor Luminal

  • Luminal A Breast Carcinoma

  • Luminal Breast Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-A0148A Halofantrine hydrochloride Inhibitor 99.90% Yes
HY-A0148 Halofantrine Inhibitor / Unkown
HY-A0148AR Halofantrine hydrochloride (Standard) Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (22)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-174497 eGFP mRNA 90% Unkown
HY-145973A 3'OMe-m7GpppAmpG ammonium solution (100 mM) Inhibitor 98.24% Unkown
HY-E70081 mRNA Cap 2'-O-methyltransferase / Unkown
HY-145973 3'OMe-m7GpppAmpG Inhibitor / Unkown
HY-145973AGL 3'OMe-m7GpppAmpG ammonium solution (100 mM) (GMP Like) Inhibitor / Unkown
HY-145973B 3'OMe-m7GpppAmpG Tris Inhibitor / Unkown
HY-145979 m7GpppUmpG / Unkown
HY-145980 m7GpppUpG / Unkown
HY-145981 m7GpppCpG / Unkown
HY-145982 m7GpppCmpG / Unkown
HY-185611 A(5')ppp(5')(2'-OMeA)pG tetraammonium / Unkown
HY-D0869S 3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 / Unkown
HY-RS01880 CAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11259 PRSS8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14969 TRAF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145976 m7GpppGpG / Unkown
HY-RS17877 Cap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17996 Traf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18185 Prss8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24071 Park7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24346 Cap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24659 Prss8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CAP1 MGD MGI:88262
Rattus norvegicus CAP1 RGD RGD:620309
Felis catus CAP1 VGNC VGNC:60346
Bos taurus CAP1 VGNC VGNC:26737
Macaca mulatta CAP1 VGNC VGNC:99860
Others CAP1 NCBI