CSNK1D - casein kinase 1 delta Gene

Also Known as ASPS; CKId; HCKID; FASPS2; CKIdelta; CKI-delta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1453

About CSNK1D

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,239,019-82,273,750 (from NCBI)

This gene has 26 transcripts (splice variants), 264 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 17.2), prostate (RPKM 17.2) and 25 other tissues.

Summary

This gene is a member of the Casein Kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of Apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

CSNK1D Products (3)

mRNA	Protein	Name
NM_001363749.2	NP_001350678.1	casein kinase I isoform delta isoform 3
NM_001893.6	NP_001884.2	casein kinase I isoform delta isoform 1
NM_139062.4	NP_620693.1	casein kinase I isoform delta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	16618118	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	19591487	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	12270943	GOA
enables protein serine kinase activity	IMP IMP: Inferred from mutant phenotype	19043076	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10606744	GOA
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	16618118	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within Golgi organization	IMP IMP: Inferred from mutant phenotype	24648492	GOA
acts upstream of or within microtubule nucleation	IMP IMP: Inferred from mutant phenotype	24648492	GOA
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	24648492	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20412773	GOA
acts upstream of or within protein localization to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	24648492	GOA
acts upstream of or within protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	24648492	GOA
acts upstream of or within protein localization to cilium	IMP IMP: Inferred from mutant phenotype	24648492	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	16618118	GOA
involved in spindle assembly	IDA IDA: Inferred from direct assay	10826492	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10826492	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	29257953	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16027726	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16027726	GOA
located in spindle	IDA IDA: Inferred from direct assay	10826492	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	10826492	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1D Protein Structure

Pkinase

0
100
200
300
415 a.a.

Protein Preferred Names	Protein Names
casein kinase I isoform delta casein kinase I	tau-protein kinase CSNK1D

Protein Preferred Names

Protein Names

casein kinase I isoform delta

casein kinase I

tau-protein kinase CSNK1D

CSNK1D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CSNK1D	P48730	DRICH1	Homo sapiens	Q6PGQ1	Validated Y2H	32296183
Intra	CSNK1D	P48730	DRICH1	Homo sapiens	Q6PGQ1	Y2H Array	32296183
Intra	CSNK1D	P48730	GAPVD1	Homo sapiens	Q14C86	Anti Tag CoIP	33961781
Intra	CSNK1D	P48730	GAPVD1	Homo sapiens	Q14C86	Pull Down	32707033
Intra	CSNK1D	P48730	GAPVD1	Homo sapiens	Q14C86	Anti Tag CoIP	35271311
Intra	CSNK1D	P48730	PER2	Homo sapiens	O15055	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	PER2	Homo sapiens	O15055	Anti Tag CoIP	33961781
Intra	CSNK1D	P48730	PER2	Homo sapiens	O15055	Y2H Array	32296183
Intra	CSNK1D	P48730	PER2	Homo sapiens	O15055	Protein Kinase Assay	21179498
Intra	CSNK1D	P48730	CCDC14	Homo sapiens	Q49A88-3	Validated Y2H	32296183
Intra	CSNK1D	P48730	CCDC14	Homo sapiens	Q49A88-3	Y2H Array	32296183
Intra	CSNK1D	P48730	CCDC14	Homo sapiens	Q49A88-3	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	IKZF4	Homo sapiens	Q9H2S9	Y2H Array	32296183
Intra	CSNK1D	P48730	IKZF4	Homo sapiens	Q9H2S9	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	IKZF4	Homo sapiens	Q9H2S9	Validated Y2H	32296183
Intra	CSNK1D	P48730	TRIM3	Homo sapiens	O75382	Y2H Array	32296183
Intra	CSNK1D	P48730	TRIM3	Homo sapiens	O75382	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	MDM2	Homo sapiens	Q00987	Pull Down	20708156
Intra	CSNK1D	P48730	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
Intra	CSNK1D	P48730	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	20708156
Intra	CSNK1D	P48730	ZNF618	Homo sapiens	Q5T7W0	Y2H Array	32296183
Intra	CSNK1D	P48730	ZNF618	Homo sapiens	Q5T7W0	Anti Tag CoIP	33961781
Intra	CSNK1D	P48730	ZNF618	Homo sapiens	Q5T7W0	Validated Y2H	32296183
Intra	CSNK1D	P48730	ZNF618	Homo sapiens	Q5T7W0	Y2H Prey Pooling	32296183
Cross	CSNK1D	P48730	Dvl2	Mus musculus	Q60838	Protein Kinase Assay	22609948
Intra	CSNK1D	P48730	TRIM9	Homo sapiens	Q9C026	Validated Y2H	25416956
Intra	CSNK1D	P48730	TRIM9	Homo sapiens	Q9C026	Y2H Prey Pooling	25416956
Intra	CSNK1D	P48730	TRIM9	Homo sapiens	Q9C026	Y2H Array	25416956
Intra	CSNK1D	P48730	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	25416956
Intra	CSNK1D	P48730	DVL3	Homo sapiens	Q92997	Y2H Pooling	16189514
Intra	CSNK1D	P48730	DVL3	Homo sapiens	Q92997	Validated Y2H	25416956
Intra	CSNK1D	P48730	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	CSNK1D	P48730	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	CSNK1D	P48730	LURAP1	Homo sapiens	Q96LR2	Validated Y2H	25416956
Intra	CSNK1D	P48730	LURAP1	Homo sapiens	Q96LR2	Anti Tag CoIP	25416956
Intra	CSNK1D	P48730	LURAP1	Homo sapiens	Q96LR2	Y2H Prey Pooling	25416956
Intra	CSNK1D	P48730	PAK5	Homo sapiens	Q9P286	Validated Y2H	32296183
Intra	CSNK1D	P48730	PAK5	Homo sapiens	Q9P286	Y2H Array	32296183
Intra	CSNK1D	P48730	PAK5	Homo sapiens	Q9P286	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	CSNK1D	P48730	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	CSNK1D	P48730	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	CSNK1D	P48730	EVI5	Homo sapiens	O60447	Y2H Array	32296183
Intra	CSNK1D	P48730	EVI5	Homo sapiens	O60447	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Advanced Sleep Phase Syndrome, Familial, 2	Advanced Sleep Phase Syndrome 2 FASPS2 Advanced Sleep-Phase Syndrome, Familial, 2 Familial Advanced Sleep Phase Syndrome 2 Sleep Phase Syndrome, Advanced, Familial, Type 2
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial
Migraine, Familial Hemiplegic, 1	FHM1 Mhp1 Fhm Familial Hemiplegic Migraine 1 Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia Migraine, Hemiplegic, Familial, Type 1 Hemiplegic Migraine, Familial Type 1
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Migraine, Familial Hemiplegic, 2	FHM2 Mhp2 Migraine, Familial Basilar Familial Hemiplegic Migraine 2 Familial Hemiplegic Migraine-2 Familiar Basilar Migraine Migraine, Hemiplegic, Familial, Type 2
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Migraine, Familial Hemiplegic, 3	FHM3 Familial Hemiplegic Migraine 3 Mhp3 Migraine, Hemiplegic, Familial, Type 3
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-148233S	JNJ-6204		99.75%	Unkown
HY-137340	WH-10417-099	Degrader	98.14%	Unkown
HY-184652	LRRK2/JNK3-IN-1	Inhibitor	/	Unkown
HY-RS03246	CSNK1D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21113	Csnk1d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27632	Csnk1d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CSNK1D	VGNC	VGNC:39667
Felis catus	CSNK1D	VGNC	VGNC:97391
Macaca mulatta	CSNK1D	VGNC	VGNC:81382
Mus musculus	CSNK1D	MGD	MGI:1355272
Rattus norvegicus	CSNK1D	RGD	RGD:71031
Bos taurus	CSNK1D	VGNC	VGNC:27766
Others	CSNK1D	NCBI