Max - Max protein Gene

Also Known as bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17187

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; lens; limb cartilage condensation; and liver. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]

Max Products (4)

mRNA Protein Name
NM_001146176.2 NP_001139648.1 protein max isoform 2
NM_001361663.2 NP_001348592.1 protein max isoform 3
NM_001361664.2 NP_001348593.1 protein max isoform 4
NM_008558.3 NP_032584.2 protein max isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
8521822 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8521822 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9764821 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20434984 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10601024 MGI
acts upstream of or within regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
8521822 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8521822 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of Myc-Max complex IPI
IPI: Inferred from physical interaction
20434984 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20434984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein max

  • myc-associated factor X

  • myc-binding novel HLH/LZ protein

  • protein myn

Max Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Max P28574 Myc Mus musculus P01108
EMSA
9764821
Intra
Max P28574 Myc Mus musculus P01108
Anti Tag CoIP
20946988
Intra
Max P28574 Myc Mus musculus P01108
Y2H Array
20211142
Intra
Max P28574 Myc Mus musculus P01108
Pull Down
20946988
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-108750 Soybean oil / Phase 4
HY-145723 MAX-40279 Inhibitor 97.04% Phase 2
HY-145723C MAX-40279 hemiadipate Inhibitor 99.26% Phase 2
HY-145723A MAX-40279 hydrochloride Inhibitor / Phase 2
HY-145723B MAX-40279 hemifumarate Inhibitor 99.52% Phase 2

Pre-clinical Phase

Bioactive Molecules (62)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-D0218 Thioflavin T 99.40% Unkown
HY-12702 10058-F4 Inhibitor 99.90% Unkown
HY-135969 Glycol chitosan Inhibitor 61.22% Unkown
HY-124675 MYCMI-6 98.57% Unkown
HY-100996 10074-G5 Inhibitor 99.63% Unkown
HY-100669 Mycro 3 Inhibitor 98.11% Unkown
HY-W016813 trans-Aconitic acid Inhibitor 99.74% Unkown
HY-144878 VPC-70619 Inhibitor 99.93% Unkown
HY-12703 KSI-3716 Inhibitor 98.98% Unkown
HY-150259 MDEG-541 Degrader 98.68% Unkown
HY-153064 MAX-10181 Inhibitor 98.56% Unkown
HY-145603A (R)-Vanzacaftor Modulator 98.02% Unkown
HY-N5072 Desmethylglycitein Inhibitor 99.99% Unkown
HY-122683 sAJM589 Inhibitor 99.47% Unkown
HY-22445 MY05 Inhibitor 99.34% Unkown
HY-131021 Janelia Fluor® 549, Azide 99.49% Unkown
HY-147291 VPC-70063 99.92% Unkown
HY-126979 Mycro2 Inhibitor 99.81% Unkown
HY-W591768 (E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide 99.66% Unkown
HY-W007648 Methyl 3-aminopropanoate hydrochloride ≥98.0% Unkown
HY-133536 PA Janelia Fluor® 549, SE 98.2% Unkown
HY-171995 Rf470 TFA / Unkown
HY-131022 Janelia Fluor® 549 TFA 85.20% Unkown
HY-DY1049 Thioflavin T (solution) / Unkown
HY-125978 JY-3-094 Inhibitor 97.04% Unkown
HY-134975 NY2267 Inhibitor 98.53% Unkown
HY-N6919 Cauloside C Inhibitor 99.66% Unkown
HY-137551 Tiafenacil Inhibitor 99.20% Unkown
HY-N6878 Cauloside D 99.69% Unkown
HY-N7273 Soyasaponin III Inducer 99.73% Unkown
HY-P10699 MAX1 95.31% Unkown
HY-115796 VU0477886 Activator / Unkown
HY-115839A Detajmium L-tartrate Inhibitor / Unkown
HY-125636 Mycro1 Inhibitor / Unkown
HY-131023 Janelia Fluor® 549, Maleimide TFA / Unkown
HY-131024 Janelia Fluor® 549, Tetrazine / Unkown
HY-136784 Rhod-2 potassium / Unkown
HY-159756B KI-MS2-008 Inhibitor / Unkown
HY-160813 DHX9-IN-18 Inhibitor / Unkown
HY-165400 TODi-1 / Unkown
HY-169334 BDK-IN-1 Inhibitor / Unkown
HY-169921 c-Myc inhibitor 15 Inhibitor / Unkown
HY-175964 MYC-MAX-IN-1 Ligand / Unkown
HY-178045 MYC-IN-4 Inhibitor / Unkown
HY-180194 SERCA2a activator 2 Activator / Unkown
HY-E71000 Lipoxidase, Glycine max (soybean) / Unkown
HY-N12273 Soyasaponin Ae / Unkown
HY-N1228 Soyacerebroside I / Unkown
HY-N18032 Glyceollin II / Unkown
HY-N18033 Glyceollin III / Unkown
HY-N4074 6"-O-Malonylglycitin / Unkown
HY-P6299 MAX8 / Unkown
HY-RS08177 MAX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W127781 Rhod-2 triammonium / Unkown
HY-136784A Rhod-2 sodium / Unkown
HY-N13282 Glyceocarpin Inhibitor / Unkown
HY-N13283 Glyceollidin I / Unkown
HY-RS17397 Max Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23852 Max Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W783575 (3R)-1-Octen-3-ol / Unkown
HY-W800768 BP Fluor 350 Azide Plus / Unkown
HY-W800769 BP Fluor 532 azide plus / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Max NCBI NCBI:4149