country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

AIM2 - absent in melanoma 2 Gene

Also Known as PYHIN4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9447

About AIM2

Cytogenetic location: 1q23.1-q23.2 Genomic coordinates (GRCh38): 1:159,055,051-159,147,132 (from NCBI)

This gene has 8 transcripts (splice variants), 48 orthologues and 3 paralogues. Biased expression in lymph node (RPKM 9.4), appendix (RPKM 5.0) and 5 other tissues.

Summary

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

AIM2 Products (2)

mRNA	Protein	Name
NM_001348247.2	NP_001335176.1	interferon-inducible protein AIM2 isoform 2
NM_004833.3	NP_004824.1	interferon-inducible protein AIM2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables cysteine-type endopeptidase activator activity	IDA IDA: Inferred from direct assay	19158679	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	19158675	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19158676	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	26197926	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19158675	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	23530044	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	19158676	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	19158675	GOA
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	19158679	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16432157	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	19158675	GOA
involved in positive regulation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	19158676	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	19158675	GOA
involved in pyroptosome complex assembly	IDA IDA: Inferred from direct assay	19158676	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	19158675	GOA
involved in tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	16432157	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of AIM2 inflammasome complex	IDA IDA: Inferred from direct assay	19158676	GOA
part of AIM2 inflammasome complex	IPI IPI: Inferred from physical interaction	24630722	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	8454910	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19158676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIM2 Protein Structure

PYRIN

HIN

0
100
200
300
343 a.a.

Protein Preferred Names	Protein Names
interferon-inducible protein AIM2

AIM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	22286270
Intra	AIM2	O14862	AIM2	Homo sapiens	O14862	Crosslink	19158676
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	19158675
Intra	AIM2	O14862	NPM1	Homo sapiens	P06748	Crosslink	30021884
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Bait CoIP	19158676
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	GMS	24630722
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	FPS	24630722
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	EM	24630722
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Tag CoIP	19158675
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Anti Tag CoIP	24237704
Intra	AIM2	O14862	PYCARD	Homo sapiens	Q9ULZ3	Pull Down	19158676
Intra	AIM2	O14862	AIM2	Homo sapiens	O14862	EM	24630722
Intra	AIM2	O14862	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	22286270

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AIM2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P72816	AIM2 Protein, Human (sf9, GST)	O14862/NP_004824.1 (M1-T343)	≥ 90%, as determined by reducing SDS-PAGE.

AIM2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83816	AIM2 Antibody (YA3513)	WB, ICC/IF, ELISA	Human
HY-P83816A	AIM2 Antibody (YA3513)(PBS only)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Brucellosis	Mediterranean Fever Malta Fever Undulant Fever Gibraltar Fever Bang'S Disease Maltese Fever Cyprus Fever Rock Fever Brucellosis Infection Brucella Infection
Tularemia	Francisella Tularensis Infection Deerfly Fever Lemming Fever Ohara Disease Pahvant Valley Plague Rabbit Fever Yatobyo
Renal Infectious Disease
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes
Muckle-Wells Syndrome	MWS Urticaria-Deafness-Amyloidosis Syndrome Uda Syndrome Neutrophilic Urticaria Urticaria, Deafness And Amyloidosis Cryopyrin-Associated Periodic Syndrome 2 Caps2 Muckle Wells Syndrome Urticaria-Deafness-Amyloidosis Cryopyrin-Associated Periodic Syndromes
Pneumonic Tularemia	Pulmonary Tularemia Bronchopneumonic Tularemia Pneumonic Tularaemia
Familial Cold Autoinflammatory Syndrome	Familial Cold Urticaria Fcas Familial Polymorphous Cold Eruption Fcu Cold Hypersensitivity
Colon Sarcoma	Colonic Sarcoma
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Salmonellosis	Salmonella Infections Salmonella Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-N0822	Shikonin	Inhibitor	99.80%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.23%	Unkown
HY-150751	ODN TTAGGG	Antagonist	99.87%	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	93.80%	Unkown
HY-152670	JC2-11	Inhibitor	98.03%	Unkown
HY-130480	Fructose-arginine	Inhibitor	98.32%	Unkown
HY-P11383	AIM2-derived decapeptide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AIM2	RGD	RGD:1307283
Mus musculus	AIM2	MGD	MGI:2686159