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Art. -Nr.: HY-153583

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HDAC8-IN-4

HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC₅₀s of 0.15 and 12 μM.

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CAS. Nr.: 1600528-05-9
Formel: C₁₇H₁₄N₂O₂S₂
Molecular Weight:342.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

HDAC8-IN-4 Chemical Structure

CAS. Nr.: 1600528-05-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC₅₀s of 0.15 and 12 μM^[1].

IC₅₀ & Target^[1]

HDAC8

0.15 μM (IC₅₀)

HDAC3

12 μM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	GI₅₀	2 μM Compound: 41	Growth inhibition of human Jurkat cells Growth inhibition of human Jurkat cells	[PMID: 37429084]

In Vitro

HDAC8-IN-4 (Compound 9) (1 to 100 μM, 5-6 days) inhibits HDAC8 protein level in HeLa cells^[1].
HDAC8-IN-4 (0-50 μM approximately, 72 h) inhibits T-cell lymphoma cells (Jurkat, HH, MT4, HUT78 cells) growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Jurkat, HH, MT4, HUT78 cells
Concentration:

0-50 μM approximately
Incubation Time:

72 h
Result:

Inhibited cell growth with IC₅₀s of 2, 7.4, 5.8, 27 μM).

Western Blot Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0-40 μM
Incubation Time:

4 h
Result:

Selectively inhibited HDAC8 over other HDACs in cells.

Chemical Information

CAS. Nr. 1600528-05-9
Molecular Weight 342.44
Formel C₁₇H₁₄N₂O₂S₂
SMILES

O=C(C1=CC=CC(C2=CSC(CSC3=CC=CC=C3)=N2)=C1)NO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Suzuki T, et al. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors. ChemMedChem. 2014 Mar;9(3):657-64. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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HDAC8-IN-4

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HDAC8-IN-4 Related Classifications

HY-153583 Related Classifications