HLX51
HLX51 is a regulatory T cell inhibitor and OX40/CD134/TNFRSF4 agonist with tumour growth inhibitory activity. HLX51 inhibits regulatory T cell differentiation and activity, relieves tumour microenvironment immunosuppression, enhances effector T cell function. HLX51 competitively binds OX40, activates OX40, promotes immune cell proliferation and T cell killing ability. HLX51 modulates immune cell function to inhibit tumour growth. HLX51 can be used for the research of advanced/metastatic solid tumours and lymphomas.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
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Biologische Aktivität
Human
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OX40L |
HLX51, an agonistic anti-OX40 humanized monoclonal antibody, activates OX40 signaling to promote immune cell proliferation and T cell killing capacity, inhibits Treg function to relieve immunosuppression, and enhances effector T cell function in preclinical in vitro immune cell-based assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TNFRSF4/OX40/CD134
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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ELISA, FACS, Functional assay
Chemical Information
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Please refer to the lot-specific COA for specific buffer information.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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