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Art. -Nr.: HY-112453

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IMDNQ1

IMDNQ1 is a Trypanosoma cruzi inhibitor derived from 1,4-naphthoquinone substituted with cyclic imide. IMDNQ1 effectively inhibits the proliferation of Trypanosoma cruzi epimastigotes, while also reducing the viability of mouse fibroblasts. The selectivity index between the antiproliferative activity and cytotoxicity of IMDNQ1 is 60.25, indicating a certain level of safety. IMDNQ1 can be widely used in studies related to Chagas disease.

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CAS. Nr.: 623163-52-0
Formel: C₁₄H₈ClNO₄
Molecular Weight:289.67

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IMDNQ1 Chemical Structure

CAS. Nr.: 623163-52-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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MEK1/2 Inhibitor

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

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In Vitro

IMDNQ1 (0.39-100 μM; 48 h) exhibits low cytotoxicity to Balb/C 3T3 mouse fibroblasts with an IC₅₀ of 165.9 μM, resulting in a selectivity index of 60.25 that is significantly higher than Nifurtimox (HY-W040073)^[1].
IMDNQ1 (0.39-100 µM; 48 h) potently inhibits the proliferation of Trypanosoma cruzi epimastigotes (Tulahuen CL98 strain) with an IC₅₀ of 2.77 µM, showing significantly greater activity than Nifurtimox (HY-W040073)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

Balb/C 3T3 mouse fibroblasts (clone A31)
Concentration:

0.39-100 µM
Incubation Time:

48 h
Result:

Reduced the viability of Balb/C 3T3 mouse fibroblasts with an IC₅₀ of 165.9 µM.
Exhibited significantly less cytotoxicity than nifurtimox (IC₅₀=114.0 µM).
Achieved a selectivity index of 60.25, which is significantly higher than the selectivity index of nifurtimox.

Related Protocols :

Chemical Information

CAS. Nr. 623163-52-0
Molecular Weight 289.67
Formel C₁₄H₈ClNO₄
SMILES

O=C1C(Cl)=C(C(=O)C=2C=CC=CC12)N3C(=O)CCC3=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Khraiwesh MH, et al. Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives. Arch Pharm Res. 2012;35(1):27-33. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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