K-252b
K-252b, an indolocarbazole isolated from the actinomycete Nocardiopsis, is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely .
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- CAS. Nr.: 99570-78-2
- Formel: C26H19N3O5
- Molecular Weight:453.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
PKC[1].
Chemical Information
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CAS. Nr. 99570-78-2
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Molecular Weight 453.45
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Formel C26H19N3O5
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SMILES
C[C@@]([C@@]1(O)C(O)=O)(O[C@](N2C3=CC=CC=C43)([H])C1)N5C(C2=C4C6=C7CNC6=O)=C7C8=CC=CC=C58
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Structure Classification
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Initial Source
Nocardiopsis Sp.K-290
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). [Content Brief]
[2]. Plomp, J.J., et al. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of α-bungarotoxin-treated rats Journal of Physiology 493, 175-186 (1996). [Content Brief]
[3]. Zhu, X., et al. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro Biochemistry Journal 323, 637-643 (1997). [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
K-252b Related Classifications
HY-N6734 Related Classifications
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