LEO 29102
LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis.
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- CAS. Nr.: 1035572-38-3
- Formel: C20H22Cl2N2O5
- Molecular Weight:441.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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PDE4 5 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| PBMC | IC50 |
16 nM
Compound: 20
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Inhibition of LPS-induced TNFalpha release in human PBMC preincubated for 30 mins before LPS stimulation measured after 18 hrs by TR-FRET assay
Inhibition of LPS-induced TNFalpha release in human PBMC preincubated for 30 mins before LPS stimulation measured after 18 hrs by TR-FRET assay
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[PMID: 24984230] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1035572-38-3
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Molecular Weight 441.31
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Formel C20H22Cl2N2O5
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SMILES
COC1=C(C=CC(C(CC2=C(C=NC=C2Cl)Cl)=O)=C1OCC(NCCC)=O)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Felding J, et al. Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. J Med Chem. 2014 Jul 24;57(14):5893-903. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LEO 29102 Related Classifications
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