LN5P45
Based on 1 publication(s) in Google Scholar
LN5P45 is an OTUB2 inhibitor (IC50: 2.3 μM). LN5P45 induces monoubiquitination of OTUB2 on lysine 31. LN5P45 can be used for research of tumor progression and metastasis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.68%
- CAS. Nr.: 3084190-39-3
- Formel: C13H15ClN2O2
- Molecular Weight:266.72
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LN5P45
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Biologische Aktivität
2.3 μM (OTUB2)[1]
Chemical Information
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CAS. Nr. 3084190-39-3
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Appearance Solid
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Molecular Weight 266.72
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Formel C13H15ClN2O2
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Color White to off-white
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SMILES
CC1=CC=CC([C@H]2C[C@@H]2C(NNC(CCl)=O)=O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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EMBO Mol Med
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke. [Abstract]2025 Apr;17(4):679-695. PMID: 40021931
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (374.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7493 mL | 18.7463 mL | 37.4925 mL | 93.7313 mL |
| 5 mM | 0.7499 mL | 3.7493 mL | 7.4985 mL | 18.7463 mL | |
| 10 mM | 0.3749 mL | 1.8746 mL | 3.7493 mL | 9.3731 mL | |
| 15 mM | 0.2500 mL | 1.2498 mL | 2.4995 mL | 6.2488 mL | |
| 20 mM | 0.1875 mL | 0.9373 mL | 1.8746 mL | 4.6866 mL | |
| 25 mM | 0.1500 mL | 0.7499 mL | 1.4997 mL | 3.7493 mL | |
| 30 mM | 0.1250 mL | 0.6249 mL | 1.2498 mL | 3.1244 mL | |
| 40 mM | 0.0937 mL | 0.4687 mL | 0.9373 mL | 2.3433 mL | |
| 50 mM | 0.0750 mL | 0.3749 mL | 0.7499 mL | 1.8746 mL | |
| 60 mM | 0.0625 mL | 0.3124 mL | 0.6249 mL | 1.5622 mL | |
| 80 mM | 0.0469 mL | 0.2343 mL | 0.4687 mL | 1.1716 mL | |
| 100 mM | 0.0375 mL | 0.1875 mL | 0.3749 mL | 0.9373 mL |
LN5P45 Related Classifications
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